Substance |
Info | Dose |
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PubMed |
Latest article |
Vitamin D3 | 📋 | ✍ | ⛔ | | 38711469 | Does vitamin D supplementation benefit patients with type 1 diabetes mellitus who are vitamin D deficient? A study was performed at the Sudan Childhood Diabetes Center from 2019 to 2022 |
Curcumin | 📋 | ✍ | ⛔ | | 38723524 | Cardioprotective effects of curcumin against Diabetic Cardiomyopathies: A systematic review and meta-analysis of preclinical studies |
Metformin | 📋 | ✍ | ⛔ | | 38486821 | Synergistic effect of metformin and vitamin D3 on osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells under high d-glucose conditions |
Berberine | 📋 | ✍ | ⛔ | | 38702033 | Berberine alleviates diabetic retinopathy by regulating the Th17/Treg ratio |
Resveratrol | 📋 | ✍ | ⛔ | | 38726423 | The protective role of resveratrol against high glucose-induced oxidative stress and apoptosis in HepG2 cells |
Melatonin | 📋 | ✍ | ⛔ | | 38486170 | Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy |
Quercetin | 📋 | ✍ | ⛔ | | 38725104 | Quercetin prevented diabetic nephropathy by inhibiting renal tubular epithelial cell apoptosis via the PI3K/AKT pathway |
Ginsenosides | 📋 | ✍ | ⛔ | | 38707641 | Ginsenosides for the treatment of insulin resistance and diabetes: Therapeutic perspectives and mechanistic insights |
Astragalosides | 📋 | ✍ | ⛔ | | 38572426 | Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation |
Magnesium | 📋 | ✍ | ⛔ | | 38271961 | Associations of the magnesium depletion score and magnesium intake with diabetes among US adults: an analysis of the National Health and Nutrition Examination Survey 2011-2018 |
Mulberry | 📋 | | ⛔ | | 38612872 | Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays |
Cinnamon | 📋 | ✍ | ⛔ | | 38290699 | Effect of cinnamon spice on continuously monitored glycemic response in adults with prediabetes: a 4-week randomized controlled crossover trial |
Nigella Sativa | 📋 | ✍ | ⛔ | | 37957516 | Topical Nigella sativa L. product: a new candidate for the management of diabetic peripheral neuropathy |
Lipoic Acid | 📋 | ✍ | ⛔ | | 38602238 | Nephro-protective effects of alpha-lipoic acid in type I diabetes |
Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38625392 | Correlation between omega-3 intake and the incidence of diabetic retinopathy based on NHANES from 2005 to 2008 |
Vitamin C | 📋 | ✍ | ⛔ | | 38727927 | Vitamin C alleviates hyperglycemic stress in retinal pigment epithelial cells |
Astragalus Root | 📋 | ✍ | ⛔ | | 38504529 | Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials |
EGCG | 📋 | ✍ | ⛔ | | 38179734 | EGCG Restores Keratinocyte Autophagy to Promote Diabetic Wound Healing through the AMPK/ULK1 Pathway |
Moringa Oleifera | 📋 | ✍ | ⛔ | | 38107449 | Flavonoid from Moringa oleifera leaves revisited: A review article on in vitro, in vivo, and in silico studies of antidiabetic insulin-resistant activity |
Ginseng | 📋 | ✍ | ⛔ | | 37777023 | Panax Quinquefolium Saponins enhances angiogenesis in rats with diabetes and myocardial infarction |
Puerarin | 📋 | ✍ | ⛔ | | 38215692 | Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease |
Astaxanthin | 📋 | ✍ | ⛔ | | 37534224 | Astaxanthin improves fatty acid dysregulation in diabetes by controlling the AMPK-SIRT1 pathway |
Fenugreek | 📋 | ✍ | ⛔ | | 38450419 | Fenugreek extract improves diabetes-induced endothelial dysfunction via the arginase 1 pathway |
Crocin | 📋 | ✍ | ⛔ | | 38419890 | Crocin protects against endoplasmic reticulum stress-related tubular injury in diabetic nephropathy via the activation of the PI3K/AKT/Nrf2 pathway |
Medicinal Plants | 📋 | | | | 38184284 | Chinese patent medicine as a complementary and alternative therapy for type 2 diabetes mellitus: A scoping review |
Hesperidin | 📋 | ✍ | ⛔ | | 38234970 | Promising influences of hesperidin and hesperetin against diabetes and its complications: a systematic review of molecular, cellular, and metabolic effects |
Naringenin | 📋 | ✍ | ⛔ | | 37866740 | Naringenin protects pancreatic β cells in diabetic rat through activation of estrogen receptor β |
Vitamin E | 📋 | ✍ | ⛔ | | 38493875 | Vitamins C, E, and beta-carotene and risk of type 2 diabetes: a systematic review and meta-analysis |
Ginger | 📋 | ✍ | ⛔ | | 38402829 | Ginger alleviates mechanical hypersensitivity and anxio-depressive behavior in rats with diabetic neuropathy through beneficial actions on gut microbiome composition, mitochondria, and neuroimmune cells of colon and spinal cord |
Stinging Nettle | 📋 | ✍ | ⛔ | | 37599855 | Phytoconstituents from Urtica dioica (stinging nettle) of Sikkim Himalaya and their molecular docking interactions revealed their nutraceutical potential as α-amylase and α-glucosidase inhibitors |
Zinc | 📋 | ✍ | ⛔ | | 38116651 | Association between Dietary Antioxidants intake and the Risk of Type 2 Diabetes Mellitus in a Prospective Cohort Study: Tehran Lipid and Glucose Study |
Saffron | 📋 | ✍ | ⛔ | | 38207245 | Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits |
Aloe Vera | 📋 | ✍ | ⛔ | | 37969667 | Effect of aloe vera juice on type 2 diabetes mellitus among Indian patients |
Genistein | 📋 | ✍ | ⛔ | | 38675531 | Genistein Prevents Apoptosis and Oxidative Stress Induced by Methylglyoxal in Endothelial Cells |
Goji Berry | 📋 | ✍ | ⛔ | | 36314308 | Potential cerebrovascular protective functions of lycium barbarum polysaccharide in alleviating hyperglycemia-aggravated cerebral ischemia/reperfusion injury in hyperglycemic rats |
Salidroside | 📋 | | | | 38243268 | Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation |
Ellagic Acid | 📋 | ✍ | ⛔ | | 37085061 | Evaluation of the effects of sinapic acid and ellagic acid on sciatic nerve in experimental diabetic rats by immunohistochemical and stereological methods |
Fucoidan | 📋 | ✍ | ⛔ | | 38635872 | Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota-Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice |
Anthocyanins | 📋 | ✍ | ⛔ | | 37810926 | Effects of anthocyanin supplementation in diet on glycemic and related cardiovascular biomarkers in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials |
Grape Seed extract | 📋 | ✍ | ⛔ | | 38367173 | Grape Seed Proanthocyanidins Protect Pancreatic β Cells Against Ferroptosis via the Nrf2 Pathway in Type 2 Diabetes |
Luteolin | 📋 | ✍ | ⛔ | | 38633216 | SIRT1/P53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and He-Ying-Qing-Re formula treatment |
Probiotics | 📋 | ✍ | ⛔ | | 38558739 | Exploring the Impact of Optimized Probiotic Supplementation Techniques on Diabetic Nephropathy: Mechanisms and Therapeutic Potential |
Food | 📋 | | | | 38198459 | Ketogenic diet preserves muscle mass and strength in a mouse model of type 2 diabetes |
Cannabidiol | 📋 | ✍ | ⛔ | | 37933286 | The pharmacology and therapeutic role of cannabidiol in diabetes |
Cocoa | 📋 | ✍ | ⛔ | | 38073976 | Neurohistopathological Alterations Induced by Theobroma Cacao and Camellia Sinensis Extracts in Diabetic Male Wistar Rats |
Pterostilbene | 📋 | ✍ | ⛔ | | 37926050 | Pterostilbene accelerates wound healing response in diabetic mice through Nrf2 regulation |
Rutin | 📋 | ✍ | ⛔ | | 37528147 | Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes |
Bee Propolis | 📋 | ✍ | ⛔ | | 38534744 | An Examination of the Effects of Propolis and Quercetin in a Rat Model of Streptozotocin-Induced Diabetic Peripheral Neuropathy |
CoQ10 | 📋 | ✍ | ⛔ | | 38524871 | Coenzyme Q10: A Key Antioxidant in the Management of Diabetes-Induced Cardiovascular Complications-An Overview of Mechanisms and Clinical Evidence |
N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 38641841 | Comparison of therapeutic effects of N-Acetylcysteine with pregabalin in improving the clinical symptoms of painful diabetic neuropathy: a randomized, double-blind clinical trial |
Kaempferol | 📋 | ✍ | ⛔ | | 38626549 | Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy |
Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38266851 | Ganoderma lucidum polysaccharide hydrogel accelerates diabetic wound healing by regulating macrophage polarization |
Blueberry | 📋 | ✍ | ⛔ | | 37627522 | Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature |
Naringin | 📋 | ✍ | ⛔ | | 38369526 | Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance |
Olive Oil | 📋 | ✍ | ⛔ | | 37979832 | EVOO supplement prevents type 1 diabetes by modulating gut microbiota and serum metabolites in NOD mice |
Polyphenols | 📋 | | | | 38726403 | Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review |
Coptis Chinensis | 📋 | | ⛔ | | 35187178 | Shenlian (SL) Decoction, a Traditional Chinese Medicine Compound, May Ameliorate Blood Glucose via Mediating the Gut Microbiota in db/db Mice |
L-Arginine | 📋 | ✍ | ⛔ | | 38430848 | Impact of L-Arginine on diabetes-induced neuropathy and myopathy: Roles of PAI-1, Irisin, oxidative stress, NF-κβ, autophagy and microRNA-29a |
Phytochemicals | 📋 | | | | 38099180 | Application of natural compounds in the treatment and prevention of prediabetes |
Pomegranate | 📋 | | ⛔ | | 37627561 | The Impact of Punica granatum Linn and Its Derivatives on Oxidative Stress, Inflammation, and Endothelial Function in Diabetes Mellitus: Evidence from Preclinical and Clinical Studies |
Vitamin B12 | 📋 | ✍ | ⛔ | | 38049026 | Neuroprotective role of vitamin B12 in streptozotocin-induced type 1 diabetic rats |
Gallic Acid | 📋 | | ⛔ | | 37723077 | Gallic acid improves the metformin effects on diabetic kidney disease in mice |
Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38264278 | Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis |
Sulforaphane | 📋 | ✍ | ⛔ | | 38611359 | Sulforaphane Ameliorates High-Fat-Diet-Induced Metabolic Abnormalities in Young and Middle-Aged Obese Male Mice |
Whey Protein | 📋 | ✍ | ⛔ | | 38076400 | Whey Protein Supplementation and Type 2 Diabetes Mellitus Risk Factors: An Umbrella Systematic Review of Randomized Controlled Trials |
Bitter Melon | 📋 | ✍ | ⛔ | | 38107145 | Saponins from Momordica charantia exert hypoglycemic effect in diabetic mice by multiple pathways |
Dihydromyricetin | 📋 | ✍ | ⛔ | | 38596141 | Dihydromyricetin regulates RIPK3-CaMKII to prevent necroptosis in high glucose-stimulated cardiomyocytes |
Fisetin | 📋 | ✍ | ⛔ | | 37996895 | Exploring the underlying mechanisms of fisetin in the treatment of hepatic insulin resistance via network pharmacology and in vitro validation |
TUDCA | 📋 | ✍ | ⛔ | | 37749820 | Tauroursodeoxycholic acid protects Schwann cells from high glucose-induced cytotoxicity by targeting NLRP3 to regulate cell migration and pyroptosis |
Micronutrients | 📋 | | ⛔ | | 38612580 | Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment |
Thymoquinone | 📋 | | ⛔ | | 37818339 | Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review |
Walnut | 📋 | | ⛔ | | 36192711 | Topical administration of Juglans regia L. leaf extract accelerates diabetic wound healing |
Baicalin | 📋 | ✍ | ⛔ | | 38687336 | Baicalin Attenuates Diabetic Cardiomyopathy In Vivo and In Vitro by Inhibiting Autophagy and Cell Death through SENP1/SIRT3 Signaling Pathway Activation |
Chlorogenic Acid | 📋 | ✍ | ⛔ | | 37690781 | Effects of Exercise Training and Chlorogenic Acid Supplementation on Hepatic Lipid Metabolism in Pre-Diabetes Mice |
Chrysin | 📋 | ✍ | ⛔ | | 35976957 | Chrysin improves diabetic nephropathy by regulating the AMPK-mediated lipid metabolism in HFD/STZ-induced DN mice |
Ferulic Acid | 📋 | ✍ | ⛔ | | 38223449 | Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid |
Gingerol | 📋 | ✍ | | | 36839182 | The Positive Effect of 6-Gingerol on High-Fat Diet and Streptozotocin-Induced Prediabetic Mice: Potential Pathways and Underlying Mechanisms |
Icariin | 📋 | ✍ | | | 38680705 | Icariin accelerates bone regeneration by inducing osteogenesis-angiogenesis coupling in rats with type 1 diabetes mellitus |
Indian Gooseberry | 📋 | | ⛔ | | 38590294 | Antidiabetic effectiveness of Phyllanthus niruri bioactive compounds via targeting DPP-IV |
Maitake Mushrooms | 📋 | | ⛔ | | 35616773 | Grifola frondosa Polysaccharide Ameliorates Early Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway |
Selenium | 📋 | ✍ | ⛔ | | 38720217 | Selenium Supplementation and Gestational Diabetes: A Randomised Controlled Trial |
Mangiferin | 📋 | | ⛔ | | 38305392 | Neuroprotective Effects of Isolated Mangiferin from Swertia chirayita Leaves Regulating Oxidative Pathway on Streptozotocin-Induced Diabetic Neuropathy in Experimental Rats |
Silymarin | 📋 | ✍ | ⛔ | | 37957854 | Testosterone with Silymarin Improves Diabetes-obesity Comorbidity Complications by Modulating Inflammatory Responses and CYP7A1/ACC Gene Expressions in Rats |
Kudzu Root | 📋 | ✍ | ⛔ | | 37802808 | [Effect and mechanism of Puerariae Lobatae Radix in alleviating insulin resistance in T2DM db/db mice based on intestinal flora] |
Ollive Leaf extract | 📋 | ✍ | ⛔ | | 37372005 | Antioxidant and Anti-Diabetic Properties of Olive ( Olea europaea) Leaf Extracts: In Vitro and In Vivo Evaluation |
Spirulina | 📋 | ✍ | ⛔ | | 36598187 | A randomized, double-blind placebo-controlled add-on trial to assess the efficacy, safety, and anti-atherogenic effect of spirulina platensis in patients with inadequately controlled type 2 diabetes mellitus |
Stevia | 📋 | ✍ | ⛔ | | 38039035 | Protective effect of Stevia on diabetic induced testicular damage: an immunohistochemical and ultrastructural study |
Flavonoids | 📋 | | ⛔ | | 37324738 | Flavonoids improve type 2 diabetes mellitus and its complications: a review |
Graviola | 📋 | ✍ | ⛔ | | 37299522 | Annona muricate Extract Supplementation Contributes to Improve Aberrant Multi-Organ Energy Metabolism via Muscle-Brain Connectivity in Diabetic Mice |
Hesperetin | 📋 | | | | 38540165 | Computational and Experimental Approaches Exploring the Role of Hesperetin in Improving Autophagy in Rat Diabetic Retinopathy |
Vitamin B9 | 📋 | ✍ | ⛔ | | 38233029 | Folic Acid and Diabetic Foot Ulcers |
Fig | 📋 | | ⛔ | | 38692894 | Antidiabetic Effect of Fig Seed Oil in Rats with Diabetes Induced by Streptozotocin |
Ginger extract | 📋 | ✍ | ⛔ | | 36900554 | The Effect of Ginger ( Zingiber officinale Roscoe) Aqueous Extract on Postprandial Glycemia in Nondiabetic Adults: A Randomized Controlled Trial |
Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 37457904 | Effect of Rhodiola rosea Rhizome and Punica granatum Fruit Peel on the Metabolic Processes and Physiological Activity of Rats Fed with Excessively Fat Diet |
Coffee | 📋 | ✍ | ⛔ | | 38398503 | The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis |
Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38680120 | Eicosapentaenoic acid activates the P62/KEAP1/NRF2 pathway for the prevention of diabetes-associated cognitive dysfunction |
Formononetin | 📋 | | | | 38104880 | Formononetin, a bioactive isoflavonoid constituent from Astragalus membranaceus (Fisch.) Bunge, ameliorates type 1 diabetes mellitus via activation of Keap1/Nrf2 signaling pathway: An integrated study supported by network pharmacology and experimental validation |
Haritaki | 📋 | ✍ | ⛔ | | 38329710 | Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study |
Inulin | 📋 | ✍ | ⛔ | | 38725443 | Inulin Reduces Kidney Damage in Type 2 Diabetic Mice by Decreasing Inflammation and Serum Metabolomics |
Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 38583241 | Boosting wound healing in diabetic rats: The role of nicotinamide riboside and resveratrol in UPR modulation and pyroptosis inhibition |
Papaya | 📋 | ✍ | ⛔ | | 38172797 | Supplementation of papaya leaf juice has beneficial effects on glucose homeostasis in high fat/high sugar-induced obese and prediabetic adult mice |
Roselle | 📋 | ✍ | ⛔ | | 38708257 | Nephroprotective Effect of Hibiscus Sabdariffa Leaf Flavonoid Extracts via KIM-1 and TGF-1β Signaling Pathways in Streptozotocin-Induced Rats |
Star Fuit | 📋 | | ⛔ | | 32606871 | Protective Effect of Benzoquinone Isolated from the Roots of Averrhoa carambola L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-κB Signaling Pathway |
Turmeric | 📋 | ✍ | ⛔ | | 38347961 | Curcuma longa extract reduces serum inflammatory markers and postprandial hyperglycemia in healthy but borderline participants with overweight and glycemia in the normal/prediabetes range: a randomized, double-blind, and placebo-controlled trial |
Almond | 📋 | | ⛔ | | 36963852 | Premeal almond load decreases postprandial glycaemia, adiposity and reversed prediabetes to normoglycemia: A randomized controlled trial |
Apigenin | 📋 | ✍ | ⛔ | | 38718570 | Apigenin suppresses epithelial-mesenchymal transition in high glucose-induced retinal pigment epithelial cell by inhibiting CBP/p300-mediated histone acetylation |
Asiatic Acid | 📋 | | | | 37283103 | Asiatic acid improves insulin secretion of β cells in type 2 diabetes through TNF- α/Mfn2 pathway |
Black Tea | 📋 | ✍ | ⛔ | | 37083054 | Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice |
Blackcurrant | 📋 | ✍ | ⛔ | | 35293002 | The antioxidant, anti-inflammatory, and antiplatelet effects of Ribes rubrum L. fruit extract in the diabetic rats |
Capsaicin | 📋 | ✍ | ⛔ | | 38700794 | Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE/IGF-1/Akt, TGF-β/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice |
Cinnamaldehyde | 📋 | | | | 38698047 | Cinnamaldehyde ameliorates STZ-induced diabetes through modulation of autophagic process in adipocyte and hepatic tissues on rats |
Green Tea | 📋 | ✍ | ⛔ | | 37083054 | Regulation of glucolipid metabolism and gut microbiota by green and black teas in hyperglycemic mice |
Lycopene | 📋 | ✍ | ⛔ | | 38444079 | Lycopene prevents cell death in NRK-52E cells by inhibition of high glucose-activated DNA damage and apoptotic, autophagic, and necrotic pathways |
Pine Bark | 📋 | ✍ | ⛔ | | 35637465 | Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats |
Salvianolic Acid | 📋 | | | | 38405620 | Salvianolic Acid B Alleviates High Glucose-Induced Vascular Smooth Muscle Cell Inflammation by Upregulating the miR-486a-5p Expression |
Cordyceps | 📋 | ✍ | ⛔ | | 38149724 | Cordyceps cicadae polysaccharides attenuate diabetic nephropathy via the miR-30a-3p/TRIM16 axis |
Diosgenin | 📋 | | | | 38371502 | Fenugreek derived diosgenin as an emerging source for diabetic therapy |
Diosmin | 📋 | ✍ | ⛔ | | 36934613 | Diosmin exerts hepatoprotective and antihyperglycemic effects against sodium arsenite-induced toxicity through the modulation of oxidative stress and inflammation in mice |
Fish Oil | 📋 | ✍ | ⛔ | | 38254166 | Comparison of the efficacy of fish oil and probiotic supplementation on glucose and lipid metabolism in patients with type 2 diabetes: a systematic review and network meta-analysis |
Garlic | 📋 | ✍ | ⛔ | | 38051214 | Evidential support for garlic supplements against diabetic kidney disease: a preclinical meta-analysis and systematic review |
Irisin | 📋 | | | | 38663105 | New insights into the roles of Irisin in diabetic cardiomyopathy and vascular diseases |
NMN | 📋 | ✍ | ⛔ | | 38473844 | Nicotinamide Mononucleotide (NMN) Works in Type 2 Diabetes through Unexpected Effects in Adipose Tissue, Not by Mitochondrial Biogenesis |
Taurine | 📋 | ✍ | ⛔ | | 38637413 | Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway |
Allicin | 📋 | ✍ | ⛔ | | 38308387 | Management of wounds in diabetes by administering allicin and quercetin in emulsion form as wound medicine in diabetic rat models |
Andrographis | 📋 | ✍ | ⛔ | | 38638635 | Andrographis Paniculata (Burm. F.) Flavonoid Compound and Prevention of Diabetic Retinopathy |
Andrographolide | 📋 | | | | 37987454 | TXNIP-NLRP3-GSDMD axis-mediated inflammation and pyroptosis of islet β-cells is involved in cigarette smoke-induced hyperglycemia, which is alleviated by andrographolide |
Apple | 📋 | | ⛔ | | 36811563 | Chronic consumption of probiotics, oats, and apples has differential effects on postprandial bile acid profile and cardiometabolic disease risk markers compared with an isocaloric control (cornflakes): a randomized trial |
Hawthorn | 📋 | ✍ | ⛔ | | 36076481 | Interval training and Crataegus persica ameliorate diabetic nephropathy via miR-126/Nrf-2 mediated inhibition of stress oxidative in rats with diabetes after myocardial ischemia-reperfusion injury |
Honey | 📋 | ✍ | ⛔ | | 37809953 | Pancreatic regenerative potential of manuka honey evidenced through pancreatic histology and levels of transcription factors in diabetic rat model |
L-Carnitine | 📋 | ✍ | ⛔ | | 37042471 | L-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-Parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways |
L-Carnosine | 📋 | ✍ | ⛔ | | 38172006 | Carnosine supplementation improves glucose control in adults with pre-diabetes and type 2 diabetes: A randomised controlled trial |
Myricetin | 📋 | | ⛔ | | 38472186 | Myricetin alleviates diabetic cardiomyopathy by regulating gut microbiota and their metabolites |
Nicotinamide | 📋 | ✍ | ⛔ | | 38446387 | Nicotinamide protects against diabetic kidney disease through regulation of Sirt1 |
Nobiletin | 📋 | ✍ | | | 36906890 | Hypoglycemic effect of NOBILETIN via Gut MICROBIOTA-Metabolism Axis on Hyperglycemic Mice |
Oleuropein | 📋 | | | | 38542759 | Oleuropein Supplementation Ameliorates Long-Course Diabetic Nephropathy and Diabetic Cardiomyopathy Induced by Advanced Stage of Type 2 Diabetes in db/ db Mice |
Piperine | 📋 | ✍ | ⛔ | | 38481895 | Studies on the Effect of Piperine on Hepatocyte Nuclear Factor 1 Alpha (HNF-1α) and Sterol Regulatory Element-Binding Protein 1c (SREBP-1c) Levels in High-Fat-Diet and Sucrose-Induced Type 2 Diabetes Mellitus Rats |
Tanshinone | 📋 | | | | 38650121 | Tanshinone IIA suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual-like protein 1 and acyl-coenzyme A synthetase long-chain family member 4 signaling pathway |
Tribulus Terrestris | 📋 | ✍ | ⛔ | | 38309487 | In-depth investigation of the therapeutic effect of Tribulus terrestris L. on type 2 diabetes based on intestinal microbiota and feces metabolomics |
Basil | 📋 | ✍ | ⛔ | | 35470646 | Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model |
Chromium | 📋 | ✍ | ⛔ | | 38474436 | Chromium Picolinate Regulates Bone Metabolism and Prevents Bone Loss in Diabetic Rats |
Date | 📋 | | ⛔ | | 36125886 | Tiger nut (Cyperus esculentus L.) and date palm (Phoenix dactylifera L.) fruit blend mitigates hyperglycemia, insulin resistance and oxidative complications in type-2 diabetes models |
Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 37051424 | Investigating the Role of EPA and DHA on Cellular Oxidative Stress; Profiling Antidiabetic and Antihypertensive Potential |
Eugenol | 📋 | | | | 38047382 | Protective role of eugenol against diabetes-induced oxidative stress, DNA damage, and apoptosis in rat testes |
Frankincense | 📋 | ✍ | ⛔ | | 35956066 | Anatomical and Functional Effects of Oral Administration of Curcuma Longa and Boswellia Serrata Combination in Patients with Treatment-Naïve Diabetic Macular Edema |
Fucoxanthin | 📋 | ✍ | ⛔ | | 35997158 | Fucoxanthin ameliorated myocardial fibrosis in STZ-induced diabetic rats and cell hypertrophy in HG-induced H9c2 cells by alleviating oxidative stress and restoring mitophagy |
Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38027999 | Potential roles of circulating microRNAs in the healing of type 1 diabetic wounds treated with green tea extract: molecular and biochemical study |
Guava | 📋 | | ⛔ | | 37722234 | Elucidation of anti-hyperglycemic activity of Psidium guajava L. leaves extract on streptozotocin induced neonatal diabetic Long-Evans rats |
Lutein | 📋 | ✍ | ⛔ | | 37274105 | The role of lutein-rich purple sweet potato leaf extract on the amelioration of diabetic retinopathy in streptozotocin-induced Sprague-Dawley rats |
Mangosteen | 📋 | ✍ | ⛔ | | 36655319 | Alpha-Mangosteen lessens high-fat/high-glucose diet and low-dose streptozotocin induced-hepatic manifestations in the insulin resistance rat model |
Neem | 📋 | ✍ | | | 36861235 | Combating effects of Azadirachta indica leaves extract on biochemical and neuropsychological decline observed in diabetes |
Red Sage | 📋 | ✍ | ⛔ | | 38640337 | Role and molecular mechanism of Salvia miltiorrhiza associated with chemical compounds in the treatment of diabetes mellitus and its complications: A review |
Vitamin A | 📋 | ✍ | ⛔ | | 38177180 | The relationship between blood vitamin A levels and diabetic retinopathy: a population-based study |
Vitamin B6 | 📋 | ✍ | ⛔ | | 38194486 | Association of vitamin B6 intake with the risk and prognosis of diabetic retinopathy: a NHANES-based study |
Angelica | 📋 | ✍ | ⛔ | | 35027136 | The structures of two polysaccharides from Angelica sinensis and their effects on hepatic insulin resistance through blocking RAGE |
Burdock | 📋 | | ⛔ | | 37970441 | Synergic effects of Trigonella foenum-graecum, Ribes rubrum, Lavandula angustifolia, and Arctium Lappa extracts mixture on learning and memory deficits in streptozocin-induced diabetic rats |
Butyrate | 📋 | | ⛔ | | 38409852 | Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex |
Chamomile | 📋 | ✍ | ⛔ | | 36302045 | Ameliorative effects of half-dose saffron and chamomile combination on Psycho-endocrinological changes in a diabetic murine model |
Dihydroquercetin | 📋 | | | | 37375642 | Taxifolin Suppresses Inflammatory Responses of High-Glucose-Stimulated Mouse Microglia by Attenuating the TXNIP-NLRP3 Axis |
Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 37450070 | Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway |
Gotu Kola | 📋 | ✍ | ⛔ | | 35368764 | Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers |
L-Glutamine | 📋 | ✍ | ⛔ | | 38013301 | The essential role of glutamine metabolism in diabetic cardiomyopathy: A review |
Paeoniflorin | 📋 | | | | 38223927 | Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy |
Procyanidins | 📋 | | ⛔ | | 37803795 | Peanut skin procyanidins reduce intestinal glucose transport protein expression, regulate serum metabolites and ameliorate hyperglycemia in diabetic mice |
PUFA | 📋 | | | | 38307219 | Molecular effects of Vitamin-D and PUFAs metabolism in skeletal muscle combating Type-II diabetes mellitus |
Rehmannia | 📋 | ✍ | ⛔ | | 37005841 | [Effects of Rehmanniae Radix and Rehmanniae Radix Praeparata on proteomics and autophagy in mice with type 2 diabetes mellitus induced by high-fat diet coupled with streptozotocin] |
Silibinin | 📋 | ✍ | | | 38726421 | Silibinin as a promising treatment for diabetes: Insights into behavioral and metabolic changes in an animal model |
Urolithins | 📋 | | | | 38392186 | Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance |
Vitamin B1 | 📋 | ✍ | ⛔ | | 37094704 | Association between diabetes and thiamine status - A systematic review and meta-analysis |
Vitamin B8 | 📋 | ✍ | ⛔ | | 37836508 | Myoinositols Prevent Gestational Diabetes Mellitus and Related Complications: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
Avocado | 📋 | ✍ | ⛔ | | 38648888 | Association between avocado consumption and diabetes in Mexican adults: Results from the 2012, 2016, and 2018 Mexican National Health and Nutrition Surveys |
Bilberry | 📋 | ✍ | ⛔ | | 34996690 | Phytochemical and pharmacological anti-diabetic properties of bilberries (Vaccinium myrtillus), recommendations for future studies |
Carvacrol | 📋 | ✍ | ⛔ | | 38154959 | Carvacrol improves blood lipid and glucose in rats with type 2 diabetes mellitus by regulating short-chain fatty acids and the GPR41/43 pathway |
Catechins | 📋 | | | | 38687305 | (+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation |
Cordycepin | 📋 | | | | 37846111 | [Effect of cordycepin on CX43 expression in the corpus cavernosum of type II diabetes induced erectile dysfunction in rats] |
Dandelion | 📋 | ✍ | ⛔ | | 34785415 | Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination |
Grape | 📋 | | ⛔ | | 37993763 | Fruits and the Risk of Type 2 Diabetes: The Korean Genome and Epidemiology Study Cohort |
Licorice Root | 📋 | ✍ | ⛔ | | 38447833 | The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice |
Psyllium | 📋 | ✍ | ⛔ | | 31919936 | The effect of psyllium consumption on weight, body mass index, lipid profile, and glucose metabolism in diabetic patients: A systematic review and dose-response meta-analysis of randomized controlled trials |
Pumpkin | 📋 | | ⛔ | | 37398913 | Evaluation of Antidiabetic and Antioxidant Activities of Fruit Pulp Extracts of Cucurbita moschata Duchesne and Cucurbita maxima Duchesne |
Punicalagin | 📋 | ✍ | ⛔ | | 35889739 | Punicalagin Protects against Diabetic Liver Injury by Upregulating Mitophagy and Antioxidant Enzyme Activities |
Quinoa | 📋 | | ⛔ | | 38223811 | Response surface methodology based development of an optimized polyherbal formulation and evaluation of its anti-diabetic and anti-obesity potential in high-fat diet-induced obese mice |
Tetrahydrocurcumin | 📋 | ✍ | | | 36971089 | Tetrahydrocurcumin Add-On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury |
Wormwood | 📋 | ✍ | ⛔ | | 38485514 | The effect of Artemisia annua L. aqueous and methanolic extracts on insulin signaling in liver of HFD/STZ diabetic mice |
Barberry | 📋 | ✍ | ⛔ | | 38282343 | Effects of Berberis vulgaris fruit extract on oxidative stress status in the kidney and liver of diabetic rats |
Beta-Glucan | 📋 | ✍ | ⛔ | | 35614982 | Oat β Glucan Ameliorates Renal Function and Gut Microbiota in Diabetic Rats |
Caffeine | 📋 | ✍ | ⛔ | | 36936261 | Appraisal of the causal effect of plasma caffeine on adiposity, type 2 diabetes, and cardiovascular disease: two sample mendelian randomisation study |
Chokeberry | 📋 | ✍ | ⛔ | | 34359426 | Efficacy and Safety of Aronia, Red Ginseng, Shiitake Mushroom, and Nattokinase Mixture on Insulin Resistance in Prediabetic Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial |
Coconut | 📋 | | ⛔ | | 38475510 | Coconut ( Cocos nucifera (L.)) Water Improves Glucose Uptake with Concomitant Modulation of Antioxidant and Purinergic Activities in Isolated Rat Psoas Muscles |
Flaxseed | 📋 | ✍ | ⛔ | | 36145115 | Acute Flaxseed Intake Reduces Postprandial Glycemia in Subjects with Type 2 Diabetes: A Randomized Crossover Clinical Trial |
Galangin | 📋 | | | | 34141169 | Galangin attenuates oxidative stress-mediated apoptosis in high glucose-induced renal tubular epithelial cells through modulating renin-angiotensin system and PI3K/AKT/mTOR pathway |
Lactobacillus plantarum | 📋 | | ⛔ | | 38510374 | Lactobacillus Plantarum Promotes Wound Healing by Inhibiting the NLRP3 Inflammasome and Pyroptosis Activation in Diabetic Foot Wounds |
Lotus | 📋 | | ⛔ | | 38223811 | Response surface methodology based development of an optimized polyherbal formulation and evaluation of its anti-diabetic and anti-obesity potential in high-fat diet-induced obese mice |
Myrrh | 📋 | ✍ | ⛔ | | 36825257 | Pharmacological Studies on the Antidiabetic, Antioxidant, and Antimicrobial Efficacies of Commiphora myrrha Resin in Streptozotocin-Induced Diabetes in Rats: A Preclinical Study |
Onion | 📋 | ✍ | ⛔ | | 36368355 | Protective effects of black onion polysaccharide on liver and kidney injury in T2DM rats through the synergistic impact of hypolipidemic and antioxidant abilities |
Phloretin | 📋 | | | | 38243397 | Phloretin: a comprehensive review of its potential against diabetes and associated complications |
Raspberry | 📋 | ✍ | ⛔ | | 34941428 | Raspberry (Rubus idaeus L.), a Promising Alternative in the Treatment of Hyperglycemia and Dyslipidemias |
Scutellarin | 📋 | | | | 38656633 | Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway |
St. Johns Wort | 📋 | ✍ | ⛔ | | 36336219 | Hypericum perforatum L. extract exerts insulinotropic effects and inhibits gluconeogenesis in diabetic rats by regulating AMPK expression and PKCε concentration |
Strawberry | 📋 | ✍ | ⛔ | | 37569180 | Antidiabetic, Antioxidative and Antihyperlipidemic Effects of Strawberry Fruit Extract in Alloxan-Induced Diabetic Rats |
Tangeretin | 📋 | | | | 35567707 | Influence of Tangeretin on the Exponential Regression of Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Nephropathy |
Trehalose | 📋 | | ⛔ | | 38058700 | The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trial |
Aged Garlic | 📋 | ✍ | ⛔ | | 36825728 | Organosulfur Compounds in Aged Garlic Extract Ameliorate Glucose Induced Diabetic Cardiomyopathy by Attenuating Oxidative Stress, Cardiac Fibrosis, and Cardiac Apoptosis |
Baicalein | 📋 | ✍ | ⛔ | | 38612466 | Unveiling Anti-Diabetic Potential of Baicalin and Baicalein from Baikal Skullcap: LC-MS, In Silico, and In Vitro Studies |
Barley | 📋 | ✍ | ⛔ | | 37940671 | Beneficial glycaemic effects of high-amylose barley bread compared to wheat bread in type 2 diabetes |
Caffeic Acid | 📋 | ✍ | ⛔ | | 37119739 | The ameliorative effect of zinc acetate with caffeic acid in the animal model of type 2 diabetes |
Chaga Mushrooms | 📋 | ✍ | ⛔ | | 38161352 | Research Progress on Application of Inonotus obliquus in Diabetic Kidney Disease |
Chlorella | 📋 | ✍ | ⛔ | | 36815029 | Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing |
Crocetin | 📋 | | | | 38057037 | Crocetin ameliorative effect on diabetic nephropathy in rats through a decrease in transforming growth factor-β and an increase in glyoxalase-I activity |
Emodin | 📋 | | ⛔ | | 37552124 | Emodin attenuate diabetic kidney disease by inhibiting ferroptosis via up regulating Nrf2 expression |
Fiber | 📋 | ✍ | ⛔ | | 38707305 | Association between dietary fiber intake and diabetic nephropathy among adult diabetes mellitus in the United States: A cross-sectional study |
Helichrysum | 📋 | | ⛔ | | 35631811 | Helichrysum Genus and Compound Activities in the Management of Diabetes Mellitus |
Kiwifruit | 📋 | ✍ | ⛔ | | 36014875 | Insoluble and Soluble Dietary Fibers from Kiwifruit ( Actinidia deliciosa) Modify Gut Microbiota to Alleviate High-Fat Diet and Streptozotocin-Induced TYPE 2 Diabetes in Rats |
L-Citrulline | 📋 | ✍ | ⛔ | | 38237764 | Anti-obesity and anti-diabetic effects of L-citrulline are sex-dependent |
Mango | 📋 | | ⛔ | | 36986450 | Antidiabetic and Anticancer Potentials of Mangifera indica L. from Different Geographical Origins |
Peanut | 📋 | | ⛔ | | 35442513 | Peanut Skin Procyanidins Ameliorates Insulin resistance via Modulation of Gut Microbiota and Gut Barrier in Type 2 Diabetic Mice |
Prebiotics | 📋 | ✍ | ⛔ | | 38292634 | Gut-targeted therapies for type 2 diabetes mellitus: A review |
Rosmarinic Acid | 📋 | ✍ | | | 37662743 | Rosemarinic acid protects β-cell from STZ-induced cell damage via modulating NF-κβ pathway |
Schisandra | 📋 | ✍ | ⛔ | | 38718889 | Petroleum ether extract of Schisandra sphenanthera prevents hyperglycemia and insulin resistance in association with modulation of sweet taste receptors and gut microbiota in T2DM rats |
Schisandrins | 📋 | | | | 37910285 | Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway |
Sweet Potato | 📋 | | ⛔ | | 37509903 | Mechanism of Anti-Diabetic Activity from Sweet Potato ( Ipomoea batatas): A Systematic Review |
Telmisartan | 📋 | | ⛔ | | 38200077 | Clinical and preclinical evidence that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers prevent diabetic peripheral neuropathy |
White Tea | 📋 | | ⛔ | | 34620309 | Forecast of ameliorating effect of dietary flavonol consumption in white tea with or without aerobic training on type 2 diabetes (T2D) in females |
Wogonin | 📋 | ✍ | ⛔ | | 35158145 | Research progress of active ingredients of Scutellaria baicalensis in the treatment of type 2 diabetes and its complications |
Yogurt | 📋 | | ⛔ | | 37811566 | Dairy intake and risk of type 2 diabetes: results of a large prospective cohort |
Zeaxanthin | 📋 | ✍ | ⛔ | | 32522479 | Lutein and Zeaxanthin Attenuates VEGF-induced Neovascularisation in Human Retinal Microvascular Endothelial Cells Through a Nox4-dependent Pathway |
Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 33114210 | Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B12, and Carnitine for 12 Months in Patients with Diabetic Neuropathy |
Antioxidants | 📋 | | ⛔ | | 38041593 | Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies |
Argan Oil | 📋 | ✍ | ⛔ | | 34068075 | In Vitro & In Vivo Anti-Hyperglycemic Potential of Saponins Cake and Argan Oil from Argania spinosa |
Arjuna | 📋 | ✍ | ⛔ | | 35739183 | Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats |
Artemisinin | 📋 | | | | 38454322 | Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice |
Aspirin | 📋 | | ⛔ | | 38142708 | Daily low-dose aspirin and incident type 2 diabetes in community-dwelling healthy older adults: a post-hoc analysis of efficacy and safety in the ASPREE randomised placebo-controlled trial |
Beta-Carotene | 📋 | ✍ | ⛔ | | 38493875 | Vitamins C, E, and beta-carotene and risk of type 2 diabetes: a systematic review and meta-analysis |
Blackberry | 📋 | | ⛔ | | 37280499 | Effect of anthocyanin-rich blackberry juice on endoplasmic reticulum stress in streptozotocin-induced diabetic rats |
Bromelain | 📋 | ✍ | ⛔ | | 38068370 | Anatomical and Functional Effects of an Oral Supplementation of Bromelain and Curcugreen in Patients with Focal Diabetic Macular Edema |
Carrot | 📋 | | ⛔ | | 34349520 | Carrot Juice Consumption Reduces High Fructose-Induced Adiposity in Rats and Body Weight and BMI in Type 2 Diabetic Subjects |
Coconut Oil | 📋 | | ⛔ | | 34354403 | Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats |
Daidzein | 📋 | ✍ | ⛔ | | 38477605 | Daidzein protects endothelial cells against high glucose-induced injury through the dual-activation of PPARα and PPARγ |
DHEA | 📋 | ✍ | ⛔ | | 36811237 | Low serum dehydroepiandrosterone levels are associated with diabetic retinopathy in patients with type 2 diabetes mellitus |
Geniposide | 📋 | | | | 37908704 | Geniposide promotes wound healing of skin ulcers in diabetic rats through PI3K/Akt pathway |
Ginkgolides | 📋 | | | | 38492884 | Ginkgolide B can alleviate spinal cord glymphatic system dysfunction and provide neuroprotection in painful diabetic neuropathy rats by inhibiting matrix metalloproteinase-9 |
Honokiol | 📋 | | | | 37580045 | Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1É‘ pathway in Schwann cells |
Okra | 📋 | | ⛔ | | 38046568 | Okra [ Abelmoschus esculentus (L.) Moench] improved blood glucose and restored histopathological alterations in splenic tissues in a rat model with streptozotocin-induced type 1 diabetes through CD8+ T cells and NF-kβ expression |
Oleanolic Acid | 📋 | | | | 37736511 | Effects of oleanolic acid administration on renal NF-kB, IL-18, IL-6, YKL-40, and KIM-1 in experimental diabetic rats |
Polydatin | 📋 | ✍ | | | 37783713 | Polydatin improves vascular endothelial function by maintaining mitochondrial homeostasis under high glucose conditions |
Pu-erh Tea | 📋 | ✍ | ⛔ | | 26253492 | Caffeine is responsible for the bloodglucose-lowering effects of green tea and Puer tea extractsin BALB/c mice |
Red Yeast Rice | 📋 | ✍ | ⛔ | | 33312555 | An antidiabetic nutraceutical combination of red yeast rice ( Monascus purpureus), bitter gourd ( Momordica charantia), and chromium alleviates dedifferentiation of pancreatic β cells in db/db mice |
Rice | 📋 | | ⛔ | | 36167362 | White rice, brown rice and the risk of type 2 diabetes: a systematic review and meta-analysis |
Sea Buckthorn | 📋 | ✍ | ⛔ | | 37614189 | Hippophae rhamnoides L. leaf extracts alleviate diabetic nephropathy via attenuation of advanced glycation end product-induced oxidative stress in db/db mice |
Skullcap | 📋 | ✍ | ⛔ | | 35351576 | The water extract of Radix scutellariae, its total flavonoids and baicalin inhibited CYP7A1 expression, improved bile acid, and glycolipid metabolism in T2DM mice |
Soy | 📋 | ✍ | ⛔ | | 36986086 | Soy Consumption and the Risk of Type 2 Diabetes and Cardiovascular Diseases: A Systematic Review and Meta-Analysis |
Spikenard | 📋 | ✍ | ⛔ | | 30668444 | Secondary metabolite profiling, cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and cognitive disorders |
Vitamin K1 | 📋 | ✍ | ⛔ | | 37235778 | Vitamin K1 Intake and Incident Diabetes in the Danish Diet, Cancer, and Health Study |
Vitamin K2 | 📋 | ✍ | ⛔ | | 36998133 | VK2 promotes osteogenic differentiation of BMSCs against high glucose exposure via modulation of intracellular oxidative stress |
Apple Vinegar | 📋 | ✍ | ⛔ | | 38028980 | The improvement effect of apple cider vinegar as a functional food on anthropometric indices, blood glucose and lipid profile in diabetic patients: a randomized controlled clinical trial |
Arctigenin | 📋 | | | | 38215692 | Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease |
Ashwagandha | 📋 | ✍ | ⛔ | | 34618296 | Anticonvulsant activity of methanolic extract of Withania cogulans in mice |
Asiaticoside | 📋 | | | | 38113341 | Cardioprotective effects of asiaticoside against diabetic cardiomyopathy: Activation of the AMPK/Nrf2 pathway |
Bee Venom | 📋 | ✍ | ⛔ | | 37274913 | Metformin and Bee Venom: a Comparative Detection of Histological Alteration of the Pancreas and Systemic Inflammatory Markers in Diabetic Mice |
Beets | 📋 | ✍ | ⛔ | | 38541120 | Nephroprotective and Anti-Diabetic Potential of Beta vulgaris L. Root (Beetroot) Methanolic Extract in a Rat Model of Type 2 Diabetes Mellitus |
Betaine | 📋 | ✍ | ⛔ | | 35413601 | The anti-diabetic potential of betaine. Mechanisms of action in rodent models of type 2 diabetes |
Calycosin | 📋 | | | | 36271546 | Calycosin modulates NLRP3 and TXNIP-mediated pyroptotic signaling and attenuates diabetic nephropathy progression in diabetic rats; An insight |
Catalpol | 📋 | | | | 37621314 | Protective effects and possible mechanisms of catalpol against diabetic nephropathy in animal models: a systematic review and meta-analysis |
Citicoline | 📋 | ✍ | ⛔ | | 35215442 | Understanding Neurodegeneration from a Clinical and Therapeutic Perspective in Early Diabetic Retinopathy |
Clove Essential Oil | 📋 | | ⛔ | | 36823346 | Therapeutic Potential of Clove Essential Oil in Diabetes: Modulation of Pro-Inflammatory Mediators, Oxidative Stress and Metabolic Enzyme Activities |
Coriander | 📋 | | ⛔ | | 37331322 | Modulatory role of Coriandrum sativum (coriander) extract against diabetic complications on the gonads of female rats and their offspring |
Cornus | 📋 | | | | 38129973 | Oral gavage delivery of Cornus officinalis extract delays type 1 diabetes onset and hyperglycemia in non-obese diabetic (NOD) mice |
Cranberry | 📋 | ✍ | ⛔ | | 38469711 | Nephroprotective effect of cranberry ( Vaccinium oxycoccos) in streptozocin-induced diabetic nephropathy in mice |
GABA | 📋 | ✍ | ⛔ | | 37694868 | [Synergistic effects of GABA and hypoglycemic drugs] |
Galangal | 📋 | ✍ | ⛔ | | 37939738 | Alpinia officinarum Hance extract ameliorates diabetic gastroparesis by regulating SCF/c-kit signaling pathway and rebalancing gut microbiota |
Gardenia | 📋 | | ⛔ | | 37107463 | Effective Therapeutic Verification of Crocin I, Geniposide, and Gardenia ( Gardenia jasminoides Ellis) on Type 2 Diabetes Mellitus In Vivo and In Vitro |
Genipin | 📋 | | | | 38626646 | Genipin ameliorates diabetic retinopathy via the HIF-1α and AGEs-RAGE pathways |
Hydroxytyrosol | 📋 | | | | 37219732 | The effects of hydroxytyrosol on Prdx6 and insulin expression in diabetic rat pancreases |
Hyperoside | 📋 | | | | 37646382 | Hyperoside mediates protection from diabetes kidney disease by regulating ROS-ERK signaling pathway and pyroptosis |
Lemon Balm | 📋 | ✍ | ⛔ | | 34004260 | The effect of Melissa officinalis L. extract on learning and memory: involvement of hippocampal expression of nitric oxide synthase and brain-derived neurotrophic factor in diabetic rats |
Mango Leaf | 📋 | | ⛔ | | 31914140 | Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats |
Milk | 📋 | | ⛔ | | 37811566 | Dairy intake and risk of type 2 diabetes: results of a large prospective cohort |
Millet | 📋 | | | | 37814770 | Managing Diabetes Mellitus With Millets: A New Solution |
Oats | 📋 | | ⛔ | | 38553358 | Use of ancient grains for the management of diabetes mellitus: A systematic review and meta-analysis |
Paeonol | 📋 | | | | 37641806 | Paeonol accelerates skin wound healing by regulating macrophage polarization and inflammation in diabetic rats |
Peony | 📋 | | ⛔ | | 37648027 | Antidiabetic and antioxidant properties of Paeonia mascula L.: In vitro and in vivo studies, and phytochemical analysis |
Pistachio | 📋 | ✍ | ⛔ | | 34481972 | Does a MediDiet with additional extra virgin olive oil (EVOO) and pistachios reduce the incidence of gestational diabetes? |
Pomegranate Seed extract | 📋 | | ⛔ | | 33302270 | Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes: A Prospective Randomized Double-Blind Placebo-Controlled Clinical Trial |
PQQ | 📋 | ✍ | ⛔ | | 35489281 | Pyrroloquinoline quinone ameliorates renal fibrosis in diabetic nephropathy by inhibiting the pyroptosis pathway in C57BL/6 mice and human kidney 2 cells |
Pumpkin Seed | 📋 | ✍ | ⛔ | | 37400700 | Cucurbita pepo seeds improve peripheral neuropathy in diabetic rats by modulating the inflammation and oxidative stress in rats |
Rapamycin | 📋 | ✍ | | | 36674739 | Effect of Sirolimus/Metformin Co-Treatment on Hyperglycemia and Cellular Respiration in BALB/c Mice |
Rhodiola | 📋 | ✍ | ⛔ | | 36434120 | Rhodiola pre-conditioning reduces exhaustive exercise-induced myocardial injury of insulin resistant mice |
Seaweeds | 📋 | | ⛔ | | 38012847 | Association between Seaweed Intake and Risk of Type 2 Diabetes Mellitus: A Prospective Cohort Study |
Sesamin | 📋 | ✍ | | | 37959677 | Sesamin: A Promising Therapeutic Agent for Ameliorating Symptoms of Diabetes |
Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 37803584 | Shiitake polysaccharides acted as a non-competitive inhibitor to α-glucosidase and inhibited glucose transport of digested starch from Caco-2 cells monolayer |
Shogaol | 📋 | | | | 31743763 | Ginger extract and its compound, 6-shogaol, attenuates painful diabetic neuropathy in mice via reducing TRPV1 and NMDAR2B expressions in the spinal cord |
Theaflavins | 📋 | ✍ | | | 38550892 | Potential anti-hyperglycemic activity of black tea theaflavins through inhibiting α-amylase |
Trans-Resveratrol | 📋 | | | | 37261387 | Low-Dose Trans-Resveratrol Ameliorates Diabetes-Induced Retinal Ganglion Cell Degeneration via TyrRS/c-Jun Pathway |
Ursolic Acid | 📋 | ✍ | ⛔ | | 37351031 | Combined Ursolic Acid and Resistance/Endurance Training Improve Type 3 Diabetes Biomarkers-Related Memory Deficits in Hippocampus of Aged Male Wistar Rats |
Zingerone | 📋 | | | | 31389247 | Modulatory effect of zingerone against STZ-nicotinamide induced type-2 diabetes mellitus in rats |
Apple Polyphenols | 📋 | | ⛔ | | 32739411 | Apple polyphenol-rich drinks dose-dependently decrease early-phase postprandial glucose concentrations following a high-carbohydrate meal: a randomized controlled trial in healthy adults and in vitro studies |
Betulinic Acid | 📋 | | | | 35538811 | Betulinic acid exerts anti-inflammatory activity in human periodontal ligament cells stimulated with lipopolysaccharide and/or high glucose |
Biochanin A | 📋 | | | | 38191438 | Biochanin A abrogates osteoclastogenesis in type 2 diabetic osteoporosis via regulating ROS/MAPK signaling pathway based on integrating molecular docking and experimental validation |
Black Pepper | 📋 | ✍ | ⛔ | | 35733641 | Viphyllin TM, a Standardized Black Pepper Extract Exerts Antihyperglycemic Effect and Improves Sciatic Nerve Conduction in High Fat Diet/Streptozotocin-Induced Diabetic Model Rats |
Buckwheat | 📋 | | ⛔ | | 37655471 | Fagopyrum tataricum ethanol extract ameliorates symptoms of hyperglycemia by regulating gut microbiota in type 2 diabetes mellitus mice |
Cardamom | 📋 | ✍ | ⛔ | | 32713360 | Supercritical carbon dioxide extracts of small cardamom and yellow mustard seeds have fasting hypoglycaemic effects: diabetic rat, predictive iHOMA2 models and molecular docking study |
Carotenoids | 📋 | ✍ | ⛔ | | 37032781 | The protective effects of flavonoids and carotenoids against diabetic complications-A review of in vivo evidence |
Cherry | 📋 | | ⛔ | | 35630771 | Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties |
Chia Seeds | 📋 | | ⛔ | | 38223811 | Response surface methodology based development of an optimized polyherbal formulation and evaluation of its anti-diabetic and anti-obesity potential in high-fat diet-induced obese mice |
Cyanidin | 📋 | ✍ | | | 38379077 | Regulation of Intestinal Flora and Immune Response by Cyanidin Exhibits Protective Effect against Type-2 Diabetes in Rat Model |
Echinacea | 📋 | ✍ | ⛔ | | 30246020 | Modulation of Diabetes Mellitus-Induced Male Rat Reproductive Dysfunction With Micro-Nanoencapsulated Echinacea purpurea Ethanol Extract |
Essential Oils | 📋 | | ⛔ | | 38003691 | Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications |
Folate | 📋 | ✍ | ⛔ | | 34894370 | Macronutrient and micronutrient intake of individuals with diabetic foot ulceration: A short report |
Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 31701699 | γ-Linolenic Acid versus α-Lipoic Acid for Treating Painful Diabetic Neuropathy in Adults: A 12-Week, Double-Placebo, Randomized, Noninferiority Trial |
Glabridin | 📋 | | | | 35596156 | Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways |
Grapefruit extract | 📋 | ✍ | ⛔ | | 25003704 | Modulation of hyperglycemia and TNFα-mediated inflammation by helichrysum and grapefruit extracts in diabetic db/db mice |
Guggul | 📋 | ✍ | ⛔ | | 37516016 | In-vivo anti-diabetic and anti-hyperlipidemic effects of natural metabolites from resin of Commiphora mukul and their in-silico to in-vitro target fishing |
Gymnema Sylvestre | 📋 | ✍ | ⛔ | | 38107140 | Unlocking the anti-diabetic potential of Gymnema sylvestre, Trigonella foenum-graecum, and their combination thereof: An in-vivo evaluation |
Krill Oil | 📋 | ✍ | ⛔ | | 36235791 | Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice |
Milk Thistle | 📋 | ✍ | ⛔ | | 35307557 | Silybins inhibit human IAPP amyloid growth and toxicity through stereospecific interactions |
Morin | 📋 | | | | 38331877 | Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways |
Mushrooms | 📋 | | ⛔ | | 38228086 | A prospective association between dietary mushroom intake and the risk of type 2 diabetes: the Korean Genome and Epidemiology Study-Cardiovascular Disease Association Study |
Oregano | 📋 | ✍ | ⛔ | | 36098212 | Oregano as a potential source of antidiabetic agents |
Soy Isoflavones | 📋 | ✍ | ⛔ | | 34236368 | Effects of soy isoflavone supplementation on patients with diabetic nephropathy: a systematic review and meta-analysis of randomized controlled trials |
Spermidine | 📋 | | | | 37445726 | Spermidine Attenuates High Glucose-Induced Oxidative Damage in Retinal Pigment Epithelial Cells by Inhibiting Production of ROS and NF-κB/NLRP3 Inflammasome Pathway |
Syringic Acid | 📋 | | | | 36960519 | Nephroprotective potential of syringic acid in experimental diabetic nephropathy: Focus on oxidative stress and autophagy |
Vegetables | 📋 | | | | 38520525 | Fresh fruit, dried fruit, raw vegetables, and cooked vegetables consumption associated with progression trajectory of type 2 diabetes: a multi-state analysis of a prospective cohort |
Vitamin K | 📋 | ✍ | ⛔ | | 37724446 | The relationship between vitamin K and T2DM: a systematic review and meta-analysis |
Vitamin K2 mk-7 | 📋 | ✍ | | | 33574019 | Evaluation of synergistic combination comprising magnesium orotate, menaquinone-7, and cholecalciferol for management of type 2 diabetes and dyslipidemia |
Vitamins | 📋 | | | | 37689144 | How vitamins act as novel agents for ameliorating diabetic peripheral neuropathy: A comprehensive overview |
Acacetin | 📋 | | | | 36892720 | Acacetin attenuates the pancreatic and hepatorenal dysfunction in type 2 diabetic rats induced by high-fat diet combined with streptozotocin |
Acai Berry | 📋 | ✍ | ⛔ | | 37584088 | Açai Berry Ameliorates Cognitive Impairment by Inhibiting NLRP3/ASC/CASP axis in STZ-Induced Diabetic Neuropathy in Mice |
Amaranth | 📋 | | ⛔ | | 35796287 | Multigrain porridge possesses superior nutritional quality, its consumption alleviates hyperglycemia, hypercholesterolemia and oxidative stress in obese-diabetic wistar rats |
Anthocyanidins | 📋 | | | | 36436987 | Anthocyanins and Curcumin: Possible Abilities of Prevention of Diabetes and Obesity via Stimulation of Glucagon-Like Peptide-1 Secretion and Induction of Beige Adipocyte Formation |
Arachidonic Acid | 📋 | ✍ | ⛔ | | 38336692 | Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans |
Arctiin | 📋 | | | | 32297701 | Arctiin attenuates high glucose-induced human retinal capillary endothelial cell proliferation by regulating ROCK1/PTEN/PI3K/Akt/VEGF pathway in vitro |
Astragalin | 📋 | | | | 37602342 | Astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats |
Avocado Oil | 📋 | | ⛔ | | 28214972 | Avocado oil induces long-term alleviation of oxidative damage in kidney mitochondria from type 2 diabetic rats by improving glutathione status |
Balloon Flower | 📋 | ✍ | ⛔ | | 38682702 | Platycodin D Ameliorates Type 2 Diabetes-Induced Myocardial Injury by Activating the AMPK Signaling Pathway |
Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38035407 | Discovery of β-sitosterol's effects on molecular changes in rat diabetic wounds and its impact on angiogenesis and macrophages |
Boswellic Acid | 📋 | ✍ | ⛔ | | 35121344 | Anti-diabetic potential of β-boswellic acid and 11-keto-β-boswellic acid: Mechanistic insights from computational and biochemical approaches |
Calcium | 📋 | ✍ | ⛔ | | 38356827 | Effect of calcium plus Vitamin-D combined with calcitriol in the treatment of patients with Type-2 diabetes and osteoporosis: A retrospective observational analysis |
Carnosic Acid | 📋 | | | | 35408495 | Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake |
Cashew | 📋 | | ⛔ | | 37255827 | Anacardium occidentale leaves extract and riboceine mitigate hyperglycemia through anti-oxidative effects and modulation of some selected genes associated with diabetes |
Cheese | 📋 | | ⛔ | | 37969456 | Causal relationship association of cheese intake with gestational hypertension and diabetes result from a Mendelian randomization study |
Chondroitin | 📋 | ✍ | ⛔ | | 37173033 | Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation |
Corn Silk | 📋 | ✍ | ⛔ | | 38132335 | Waste to Medicine: Evidence from Computational Studies on the Modulatory Role of Corn Silk on the Therapeutic Targets Implicated in Type 2 Diabetes Mellitus |
Dairy | 📋 | | | | 37811566 | Dairy intake and risk of type 2 diabetes: results of a large prospective cohort |
Dioscin | 📋 | | | | 38154275 | Dioscin: Therapeutic potential for diabetes and complications |
Elderberry | 📋 | ✍ | ⛔ | | 28303711 | Phenolic Elderberry Extracts, Anthocyanins, Procyanidins, and Metabolites Influence Glucose and Fatty Acid Uptake in Human Skeletal Muscle Cells |
Eucalyptus | 📋 | ✍ | ⛔ | | 36005629 | Insulin Secretory Actions of Ethanol Extract of Eucalyptus citriodora Leaf, including Plasma DPP-IV and GLP-1 Levels in High-Fat-Fed Rats, as Well as Characterization of Biologically Effective Phytoconstituents |
Flaxseed Oil | 📋 | ✍ | ⛔ | | 37685162 | Beneficial Effects of Dietary Flaxseed Oil through Inflammation Pathways and Gut Microbiota in Streptozotocin-Induced Diabetic Mice |
Fo-Ti Root | 📋 | ✍ | ⛔ | | 36076547 | Radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the HDAC4/JNK pathway |
Fruits | 📋 | | | | 38520525 | Fresh fruit, dried fruit, raw vegetables, and cooked vegetables consumption associated with progression trajectory of type 2 diabetes: a multi-state analysis of a prospective cohort |
Glucosamine | 📋 | ✍ | ⛔ | | 37329549 | Glucosamine effects on platelet aggregation of type 2 diabetes mellitus patients: in vitro assays |
Hypericin | 📋 | | | | 37956650 | Effects of Hypericin on Cultured Primary Normal Human Dermal Fibroblasts Under Increased Oxidative Stress |
Iodine | 📋 | ✍ | ⛔ | | 36907050 | Association of urinary iodine concentration with prediabetes/diabetes in adults: Analysis of the NHANES 2005-2016 |
Isoliquiritigenin | 📋 | | | | 37368032 | Isoliquiritigenin attenuates high glucose-induced proliferation, inflammation, and extracellular matrix deposition in glomerular mesangial cells by suppressing JAK2/STAT3 pathway |
Kacip Fatimah | 📋 | ✍ | ⛔ | | 35673507 | Protective effects of Labisia pumila against neuropathy in a diabetic rat model |
Knotweed | 📋 | ✍ | ⛔ | | 31289648 | Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes |
Kombucha | 📋 | ✍ | ⛔ | | 37588049 | Kombucha tea as an anti-hyperglycemic agent in humans with diabetes - a randomized controlled pilot investigation |
L-Lysine | 📋 | ✍ | ⛔ | | 38004100 | Arginine and Lysine Supplementation Potentiates the Beneficial β-Hydroxy ß-Methyl Butyrate (HMB) Effects on Skeletal Muscle in a Rat Model of Diabetes |
Lavender | 📋 | ✍ | ⛔ | | 37970441 | Synergic effects of Trigonella foenum-graecum, Ribes rubrum, Lavandula angustifolia, and Arctium Lappa extracts mixture on learning and memory deficits in streptozocin-induced diabetic rats |
Licochalcones | 📋 | | | | 37850242 | Licochalcone A alleviates abnormal glucolipid metabolism and restores energy homeostasis in diet-induced diabetic mice |
Linoleic Acid | 📋 | ✍ | ⛔ | | 38075067 | Causal relationship between linoleic acid and type 2 diabetes and glycemic traits: a bidirectional Mendelian randomization study |
Loquat | 📋 | ✍ | ⛔ | | 35962799 | Protective mechanisms of loquat leaf extract and ursolic acid against diabetic pro-inflammation |
Lychee | 📋 | | ⛔ | | 37703661 | Lychee seed polyphenol ameliorates DR via inhibiting inflammasome/apoptosis and angiogenesis in hRECs and db/db mice |
Magnolol | 📋 | | | | 36122436 | Magnolol effectively ameliorates diabetic peripheral neuropathy in mice |
Nutmeg | 📋 | ✍ | ⛔ | | 35275149 | Phenylpropanoids and neolignans isolated from Myristica fragrans enhance glucose uptake in myotubes |
Olive Polyphenols | 📋 | | | | 33546278 | Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival |
Persimmon | 📋 | | ⛔ | | 38070815 | Hypoglycemic activity of immature persimmon (Diospyros kaki Thunb.) extracts and its inhibition mechanism for α-amylase and α-glucosidase |
Rosehip | 📋 | ✍ | ⛔ | | 38283449 | Effects of Daily Intake of Rosehip Extract on Low-Density Lipoprotein Cholesterol and Blood Glucose Levels: A Systematic Review |
Sage | 📋 | ✍ | ⛔ | | 33468193 | A combination of herbal compound (SPTC) along with exercise or metformin more efficiently alleviated diabetic complications through down-regulation of stress oxidative pathway upon activating Nrf2-Keap1 axis in AGE rich diet-induced type 2 diabetic mice |
Senolytics | 📋 | | | | 36091769 | Senolytics in the treatment of diabetic retinopathy |
Sirtuin Activators | 📋 | | | | 36225477 | Role of Sirtuins in Diabetes and Age-Related Processes |
Spices | 📋 | | | | 38542668 | Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subjects: A Systematic Review and Meta-Analysis |
Tea | 📋 | | | | 37647847 | Daily higher tea consumption is associated with a reduced risk of type 2 diabetes: A cohort study and updated systematic review and meta-analysis |
Thymol | 📋 | ✍ | ⛔ | | 30103218 | In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats |
UDCA | 📋 | ✍ | ⛔ | | 38455850 | Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Clinical Study |
Vitamin B Complex | 📋 | | ⛔ | | 37189771 | Physiological Associations between Vitamin B Deficiency and Diabetic Kidney Disease |
Vitamin B3 | 📋 | ✍ | ⛔ | | 33761625 | The efficacy of niacin supplementation in type 2 diabetes patients: Study protocol of a randomized controlled trial |
Vitexin | 📋 | | | | 37172926 | Vitexin ameliorated diabetic nephropathy via suppressing GPX4-mediated ferroptosis |
Wine | 📋 | | ⛔ | | 36250602 | Moderate alcohol drinking with meals is related to lower incidence of type 2 diabetes |
Yam | 📋 | | | | 37856796 | Meta-analysis of Huangqi (Astragalus membranaceus) and Chinese Yam (Rhizoma Dioscoreae) for Diabetic Nephropathy |
Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 35830775 | Omega-3 polyunsaturated fatty acid biomarkers and risk of type 2 diabetes, cardiovascular disease, cancer, and mortality |
Anethole | 📋 | | | | 36404830 | Renoprotective activity of anethole- rich fraction from aromatic herbs on junk food induced diabetic nephropathy in rats |
Anise | 📋 | ✍ | ⛔ | | 31724151 | Aqueous anise extract alleviated the pancreatic changes in streptozotocin-induced diabetic rat model via modulation of hyperglycaemia, oxidative stress, apoptosis and autophagy: a biochemical, histological and immunohistochemical study |
Artichoke | 📋 | ✍ | ⛔ | | 35440936 | Administration of Jerusalem artichoke reduces the postprandial plasma glucose and glucose-dependent insulinotropic polypeptide (GIP) concentrations in humans |
Asafoetida | 📋 | ✍ | ⛔ | | 35474229 | Ferula assa-foetida oleo gum resin ethanolic extract alleviated the pancreatic changes and antioxidant status in streptozotocin-induced diabetic rats: A biochemical, histopathological, and ultrastructural study |
Bamboo | 📋 | ✍ | ⛔ | | 36712536 | Comparison of physicochemical and in vitro hypoglycemic activity of bamboo shoot dietary fibers from different regions of Yunnan |
Bean | 📋 | | ⛔ | | 37960148 | Minimal Effective Dose of Beans Required to Elicit a Significantly Lower Glycemic Response Than Commonly Consumed Starchy Foods: Predictions Based on In Vitro Digestion and Carbohydrate Analysis |
Berries | 📋 | | | | 32825710 | Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications |
Brazil Nut | 📋 | | ⛔ | | 38575248 | Brazil nut consumption reduces DNA damage in overweight type 2 diabetes mellitus patients |
Broccoli | 📋 | | ⛔ | | 35465108 | Brassica oleracea Extracts Prevent Hyperglycemia in Type 2 Diabetes Mellitus |
Captopril | 📋 | | | | 33536102 | Comparative study of the efficacy of captopril, simvastatin, and L-carnitine as cardioprotective drugs in children with type 1 diabetes mellitus: a randomised controlled trial |
Cardamonin | 📋 | | | | 35219163 | Cardamonin protects from diabetes-induced kidney damage through modulating PI3K/AKT and JAK/STAT signaling pathways in rats |
Cat's Claw | 📋 | ✍ | ⛔ | | 37968654 | Effect of Uncaria tomentosa aqueous extract on the response to palmitate-induced lipotoxicity in cultured skeletal muscle cells |
Chicory | 📋 | ✍ | ⛔ | | 34900765 | The impact of cichorium intybus L. On GDF-15 level in obese diabetic albino mice as compared with metformin effect |
Choline | 📋 | ✍ | ⛔ | | 33745432 | Combination Approaches Targeting Neurodegeneration, Oxidative stress and Inflammation in the Treatment of Diabetic Retinopathy |
Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 35164117 | Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations |
Clove | 📋 | | ⛔ | | 36080496 | Integrating Pharmacological and Computational Approaches for the Phytochemical Analysis of Syzygium cumini and Its Anti-Diabetic Potential |
Costus | 📋 | ✍ | ⛔ | | 34109498 | Increased insulin and GLUT2 gene expression and elevated glucokinase activity in β-like cells of islets of langerhans differentiated from human haematopoietic stem cells on treatment with Costus igneus leaf extract |
Diallyl Trisulfide | 📋 | | | | 38185348 | Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210 |
Escin | 📋 | ✍ | ⛔ | | 34383591 | Abrogation of cardiomyopathy in diabetic rats by escin - possible role of NF-κβ and MCP-1 |
Eucommia | 📋 | ✍ | ⛔ | | 37889854 | Cardioprotection of Eucommiae Folium: the extract and pharmaceutically active compounds attenuate hyperglycemia, mitochondrial dysfunction, calcium dyshomeostasis, insulin resistance, and oxidative stress in diabetic cardiomyopathy db/db mice |
Evening Primrose Oil | 📋 | ✍ | ⛔ | | 31497576 | Evening Primrose ( Oenothera biennis) Oil in Management of Female Ailments |
Fennel | 📋 | ✍ | ⛔ | | 33598196 | The hepatoprotective effects of fennel seeds extract and trans-Anethole in streptozotocin-induced liver injury in rats |
Geraniol | 📋 | | | | 35312192 | Geraniol ameliorates the progression of high fat-diet/streptozotocin-induced type 2 diabetes mellitus in rats via regulation of caspase-3, Bcl-2, and Bax expression |
Glycyrrhetinic Acid | 📋 | | | | 38222784 | Potential therapeutic targets for the prevention of diabetic nephropathy: Glycyrrhetinic acid |
Holy Basil | 📋 | ✍ | ⛔ | | 28400848 | The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature |
Honeysuckle | 📋 | | ⛔ | | 38066346 | Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy |
Horny Goat Weed | 📋 | ✍ | ⛔ | | 32420141 | Effect of icariside II and metformin on penile erectile function, glucose metabolism, reaction oxygen species, superoxide dismutase, and mitochondrial autophagy in type 2 diabetic rats with erectile dysfunction |
Horse Chestnut | 📋 | ✍ | ⛔ | | 32407839 | Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats |
Isoquercitrin | 📋 | | | | 34626776 | Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-κB pathway |
Isorhamnetin | 📋 | | | | 38445617 | Isorhamnetin as a potential therapeutic agent for diabetes mellitus through PGK1/AKT activation |
Jujube | 📋 | | ⛔ | | 38562322 | Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models |
L-Alanine | 📋 | ✍ | ⛔ | | 36125865 | Coadministration of L-alanine and L-glutamine ameliorate blood glucose levels, biochemical indices and histological features in alloxan-induced diabetic rats |
Laminaria | 📋 | ✍ | ⛔ | | 38134985 | Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: A multi-omics mechanistic analysis |
Lemon | 📋 | | ⛔ | | 35013789 | Glycemic response, satiety, gastric secretions and emptying after bread consumption with water, tea or lemon juice: a randomized crossover intervention using MRI |
Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 25402675 | Antinociceptive and antihyperglycemic effects of Melissa officinalis essential oil in an experimental model of diabetes |
Lettuce | 📋 | | ⛔ | | 35101010 | In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa |
Lingonberry | 📋 | | ⛔ | | 29888863 | Lingonberry Extract Provides Neuroprotection by Regulating the Purinergic System and Reducing Oxidative Stress in Diabetic Rats |
Marigold | 📋 | ✍ | ⛔ | | 27680049 | Low-level laser therapy and Calendula officinalis in repairing diabetic foot ulcers |
Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 38588017 | Modified Citrus Pectin (MCP) Confers a Renoprotective Effect on Early-Stage Nephropathy in Type-2 Diabetic Mice |
MUFA | 📋 | | ⛔ | | 38075228 | Monounsaturated and polyunsaturated fatty acids concerning prediabetes and type 2 diabetes mellitus risk among participants in the National Health and Nutrition Examination Surveys (NHANES) from 2005 to March 2020 |
Myrtle | 📋 | ✍ | ⛔ | | 32652914 | The Effect of Myrtus communis Aqueous Extract-Containing Gel on Wound Healing in Streptozotocin-Induced Diabetic Rats |
Nattokinase | 📋 | ✍ | ⛔ | | 37403338 | Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy |
Neferine | 📋 | | | | 38213238 | Neferine inhibits the progression of diabetic nephropathy by modulating the miR-17-5p/nuclear factor E2-related factor 2 axis |
Nuts | 📋 | | ⛔ | | 36839236 | Nuts in the Prevention and Management of Type 2 Diabetes |
Orange | 📋 | | ⛔ | | 38257135 | Effect of 100% Orange Juice and a Volume-Matched Sugar-Sweetened Drink on Subjective Appetite, Food Intake, and Glycemic Response in Adults |
Prickly Pear | 📋 | | ⛔ | | 37054824 | Protective effects and mechanisms of opuntia polysaccharide in animal models of diabetes mellitus: A systematic review and meta-analysis |
Red Clover | 📋 | ✍ | ⛔ | | 35164615 | Trifolium pratense extract increases testosterone and improves sperm characteristics and antioxidant status in diabetic rats |
Rhubarb | 📋 | | ⛔ | | 37126207 | The effects of the Rheum ribes plant extract on inflammation, extracellular matrix remodeling, and obesity suggest a therapeutic potential |
Rosemary | 📋 | ✍ | ⛔ | | 33016104 | Antidiabetic Effects and Mechanisms of Rosemary ( Rosmarinus officinalis L.) and its Phenolic Components |
Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 37016650 | Assessment of Effects of Rosemary Essential Oil on the Kidney Pathology of Diabetic Adult Male Albino Rats |
Safranal | 📋 | | | | 37324874 | Comparison of the effect of saffron, crocin, and safranal on serum levels of oxidants and antioxidants in diabetic rats: A systematic review and meta-analysis of animal studies |
Sesame Oil | 📋 | | ⛔ | | 35708633 | Methylsulfonylmethane and Sesame Seed Oil Improve Dyslipidemia and Modulate Polyunsaturated Fatty Acid Metabolism in Two Mouse Models of Diabetes |
Soy Protein | 📋 | ✍ | ⛔ | | 37890205 | Protective effect of soy isolate protein against streptozotocin induced gestational diabetes mellitus via TLR4/MyD88/NF-κB signaling pathway |
Stigmasterol | 📋 | | | | 28970778 | Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter |
Thyme | 📋 | ✍ | ⛔ | | 35368767 | The Effect of Thymus vulgaris on Hepatic Enzymes Activity and Apoptosis-Related Gene Expression in Streptozotocin-Induced Diabetic Rats |
Withaferin A | 📋 | | | | 37848702 | Withaferin-A attenuates diabetes mellitus induced male reproductive dysfunction mediated by ERα in brain and testes of Swiss albino mice |
Wood Ear Mushrooms | 📋 | | ⛔ | | 36144789 | Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice |
Aloe-Emodin | 📋 | | | | 35518350 | Aloe-Emodin Ameliorates Diabetic Nephropathy by Targeting Interferon Regulatory Factor 4 |
Amygdalin | 📋 | ✍ | ⛔ | | 37422064 | Effects of amygdalin on ferroptosis and oxidative stress in diabetic retinopathy progression via the NRF2/ARE signaling pathway |
Ashitaba | 📋 | ✍ | ⛔ | | 36235163 | Assessment of the Hypoglycemic and Hypolipidemic Activity of Flavonoid-Rich Extract from Angelica keiskei |
Bacopa Monnieri | 📋 | ✍ | ⛔ | | 38380214 | Analyzing the Antihyperglycemic Effect of Cissus quadrangularis and Bacopa monnieri on 3T3-L1 Cell Lines |
Banana | 📋 | | ⛔ | | 36200727 | Diet supplemented with boiled unripe plantain (Musa paradisiaca) exhibited antidiabetic potentials in streptozotocin-induced Wistar rats |
Bay Leaf | 📋 | | ⛔ | | 33520200 | Biomedical effects of Laurus nobilis L. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental research |
BCAA | 📋 | ✍ | ⛔ | | 37975111 | Association between type 2 diabetes and branched chain amino acids (BCAA); a case-control study |
Bee Pollen | 📋 | ✍ | ⛔ | | 33947088 | Bee Bread Can Alleviate Lipid Abnormalities and Impaired Bone Morphology in Obese Zucker Diabetic Rats |
Bergamot | 📋 | ✍ | ⛔ | | 34371986 | Effects of Bergamot Polyphenols on Mitochondrial Dysfunction and Sarcoplasmic Reticulum Stress in Diabetic Cardiomyopathy |
Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 30501605 | Hypoglycemic and Hypolipemic Effects of a New Lecithin Formulation of Bergamot Polyphenolic Fraction: A Double Blind, Randomized, Placebo- Controlled Study |
Beta-Cryptoxanthin | 📋 | | | | 33047760 | Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin |
Bilobalide | 📋 | | | | 35932369 | Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats |
Cabbage | 📋 | | ⛔ | | 37292279 | In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice |
Carnosol | 📋 | | | | 36300534 | Carnosol attenuates high glucose damage in human retinal endothelial cells through regulation of ERK/Nrf2/HO-1 pathway |
Chickpea | 📋 | | ⛔ | | 37589303 | Antioxidant, anti-inflammatory, hypoglycemic, and anti-hyperglycemic activity of chickpea protein hydrolysates evaluated in BALB-c mice |
Chicoric Acid | 📋 | | | | 38525833 | Chicoric acid advanced PAQR3 ubiquitination to ameliorate ferroptosis in diabetes nephropathy through the relieving of the interaction between PAQR3 and P110α pathway |
Chrysanthemum | 📋 | ✍ | ⛔ | | 36677639 | Analysis of Chemical Constituents of Chrysanthemum morifolium Extract and Its Effect on Postprandial Lipid Metabolism in Healthy Adults |
Cinnamic Acid | 📋 | | | | 38347789 | Uncovering the Mechanisms of Cinnamic Acid Treating Diabetic Nephropathy Based on Network Pharmacology, Molecular Docking, and Experimental Validation |
Citrus Fruits | 📋 | | ⛔ | | 35796456 | Effect of Citrus Flavanones on Diabetes; A Systematic Review |
Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 30012894 | Phytochemical Compositions and Antidiabetic Potentials of Salvia sclarea L. Essential Oils |
Coumaric acid | 📋 | | | | 30021345 | Modulation of hyperglycemia and dyslipidemia in experimental type 2 diabetes by gallic acid and p-coumaric acid: The role of adipocytokines and PPARγ |
Creatine | 📋 | ✍ | ⛔ | | 35399942 | A Hypothesis From Metabolomics Analysis of Diabetic Retinopathy: Arginine-Creatine Metabolic Pathway May Be a New Treatment Strategy for Diabetic Retinopathy |
Dihydroartemisinin | 📋 | | | | 37314293 | Topical Dihydroartemisinin Improves Wound Healing in Diabetic Mice |
Echinacoside | 📋 | | | | 38569512 | Beneficial effects of Echinacoside on cognitive impairment and diabetes in type 2 diabetic db/db mice |
Egg | 📋 | | ⛔ | | 36040350 | Egg yolk oil accelerates wound healing in streptozotocin induced diabetic rats |
Essential Fatty Acids | 📋 | ✍ | | | 32919185 | ω-6/ω-3 fatty acid ratio as an essential predictive biomarker in the management of type 2 diabetes mellitus |
Eucalyptol | 📋 | | | | 33076507 | Eucalyptol Inhibits Amyloid-β-Induced Barrier Dysfunction in Glucose-Exposed Retinal Pigment Epithelial Cells and Diabetic Eyes |
Fermented Foods | 📋 | | ⛔ | | 37799064 | Fermented soybean foods and diabetes |
Forskolin | 📋 | ✍ | ⛔ | | 33564685 | Forskolin Protected against Streptozotocin-Induced Diabetic Cardiomyopathy via Inhibition of Oxidative Stress and Cardiac Fibrosis in Mice |
Geranium | 📋 | | | | 35170422 | Effect of Pelargonium graveolens on Glucose Metabolism in Streptozotocin-Induced Diabetic Rats |
Giloy | 📋 | ✍ | ⛔ | | 37907489 | Cardioprotective Role of Tinospora cordifolia against Trimethylamine-NOxide and Glucose Induced Stress in Rat Cardiomyocytes |
Iron | 📋 | ✍ | ⛔ | | 36432476 | Iron Supplementation in Pregnancy and Risk of Gestational Diabetes: A Narrative Review |
Isoflavones | 📋 | ✍ | ⛔ | | 35807748 | Isoflavone Protects the Renal Tissue of Diabetic Ovariectomized Rats via PPARγ |
L-Histidine | 📋 | ✍ | ⛔ | | 36404849 | Protective effect of acetylcysteine, histidine, and their combination against diabetes vascular complications in type-2 diabetic rats via reducing NF-kβ pathway signaling |
L-Leucine | 📋 | ✍ | ⛔ | | 35321336 | The Association Between Leucine and Diabetic Retinopathy in Different Genders: A Cross-Sectional Study in Chinese Patients With Type 2 Diabetes |
L-Theanine | 📋 | ✍ | ⛔ | | 31076414 | Serum Ethylamine Levels as an Indicator of l-Theanine Consumption and the Risk of Type 2 Diabetes in a General Japanese Population: The Hisayama Study |
Lauric Acid | 📋 | ✍ | | | 37211320 | Lauric acid improves hormonal profiles, antioxidant properties, sperm quality and histomorphometric changes in testis and epididymis of streptozotocin-induced diabetic infertility rats |
Ligustilide | 📋 | | | | 33241003 | Ligustilide alleviates podocyte injury via suppressing the SIRT1/NF-κB signaling pathways in rats with diabetic nephropathy |
Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 37270132 | Structural characterization of Hericium erinaceus polysaccharides and the mechanism of anti-T2DM by modulating the gut microbiota and metabolites |
Liquiritigenin | 📋 | | | | 32707499 | Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NFκB balance and NLRP3 expression |
Long Pepper | 📋 | | ⛔ | | 37821784 | The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction |
Lupeol | 📋 | | | | 35792182 | Amelioration of oxidative stress mediated inflammation and apoptosis in pancreatic islets by Lupeol in STZ-induced hyperglycaemic mice |
Malvidin | 📋 | | | | 34416477 | Hypoglycemic and hypolipidemic effects of blueberry anthocyanins by AMPK activation: In vitro and in vivo studies |
Mastic | 📋 | ✍ | ⛔ | | 37796709 | Expediting Multiple Biological Properties of Limonene and α-Pinene: Main Bioactive Compounds of Pistacia lentiscus L., Essential Oils |
MSM | 📋 | ✍ | ⛔ | | 35708633 | Methylsulfonylmethane and Sesame Seed Oil Improve Dyslipidemia and Modulate Polyunsaturated Fatty Acid Metabolism in Two Mouse Models of Diabetes |
Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 15234770 | Hypoglycaemic effects of myrtle oil in normal and alloxan-diabetic rabbits |
Nimbolide | 📋 | | | | 35212444 | Protective effect of nimbolide against streptozotocin induced gestational diabetes mellitus in rats via alteration of inflammatory reaction, oxidative stress, and gut microbiota |
Noni | 📋 | | ⛔ | | 35175775 | Glycolipid Metabolism and Metagenomic Analysis of the Therapeutic Effect of a Phenolics-Rich Extract from Noni Fruit on Type 2 Diabetic Mice |
Nuciferine | 📋 | | | | 34636388 | Nuciferine administration in C57BL/6J mice with gestational diabetes mellitus induced by a high-fat diet: the improvement of glycolipid disorders and intestinal dysbacteriosis |
Peach | 📋 | | ⛔ | | 34522198 | Antidiabetic potential of the isolated fractions from the plants of Rosaceae family in streptozotocin-induced diabetic rats |
Pectin | 📋 | ✍ | ⛔ | | 34139119 | Bioactive Dietary Fibers Selectively Promote Gut Microbiota to Exert Antidiabetic Effects |
Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 28922713 | Peppermint essential oil alleviates hyperglycemia caused by streptozotocin- nicotinamide-induced type 2 diabetes in rats |
Perilla | 📋 | ✍ | | | 37329971 | Perillaldehyde improves diabetic cardiomyopathy by upregulating miR-133a-3p to regulate GSK-3β |
Poria Mushrooms | 📋 | ✍ | | | 38301984 | Bioactive triterpenoid compounds of Poria cocos (Schw.) Wolf in the treatment of diabetic ulcers via regulating the PI3K-AKT signaling pathway |
Postbiotics | 📋 | | | | 38500583 | Postbiotics: emerging therapeutic approach in diabetic retinopathy |
Potassium | 📋 | ✍ | ⛔ | | 38049705 | Dietary Potassium and Magnesium Intake with Risk of Type 2 Diabetes Mellitus Among Rural China: the Henan Rural Cohort Study |
Potato | 📋 | | ⛔ | | 36117546 | Potato consumption is not associated with cardiometabolic health outcomes in Framingham Offspring Study adults |
Pregnenolone | 📋 | ✍ | ⛔ | | 31581126 | The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose-response analysis from Henan Rural Cohort |
Proanthocyanidins | 📋 | | | | 36698506 | Upregulation of GLUT4 and PI3K, and downregulation of GSK3 mediate the anti-hyperglycemic effects of proanthocyanidins |
Retinoic Acid | 📋 | | | | 35145896 | The effects of all trans retinoic acid, vitamin D3 and their combination on plasma levels of miRNA-125a-5p, miRNA-34a, and miRNA-126 in an experimental model of diabetes |
Safflower | 📋 | ✍ | ⛔ | | 34961267 | The Modulation of Nrf-2/HO-1 Signaling Axis by Carthamus tinctorius L. Alleviates Vascular Inflammation in Human Umbilical Vein Endothelial Cells |
Sage Essential Oil | 📋 | | ⛔ | | 30372910 | Metabolic impairments and tissue disorders in alloxan-induced diabetic rats are alleviated by Salvia officinalis L. essential oil |
Sesame | 📋 | ✍ | ⛔ | | 35043479 | Consumption of sesame seeds and sesame products has favorable effects on blood glucose levels but not on insulin resistance: A systematic review and meta-analysis of controlled clinical trials |
Shea | 📋 | | ⛔ | | 33364595 | Hypoglycemic, antidyslipidemic and antioxydant effects of Vitellaria paradoxa barks extract on high-fat diet and streptozotocin-induced type 2 diabetes rats |
Spinach | 📋 | | ⛔ | | 37696865 | Accelerated wound healing induced by spinach extract in experimental model diabetic rats with streptozotocin |
St. Johns Wort Oil | 📋 | | ⛔ | | 35373654 | Effects of Hypericum scabrum L. essential oil on wound healing in streptozotocin-induced diabetic rats |
Star Anise | 📋 | ✍ | ⛔ | | 37612867 | Antidiabetic Effect of Star Anise (Illicium Verum) in Streptozotocin-induced Diabetic Rats |
Tannic Acid | 📋 | ✍ | ⛔ | | 35082680 | Tannins in the Treatment of Diabetic Neuropathic Pain: Research Progress and Future Challenges |
Tea Polyphenols | 📋 | | | | 38286317 | Targeting ERS-mitophagy in hippocampal neurons to explore the improvement of memory by tea polyphenols in aged type 2 diabetic rats |
Turkey Tail Mushrooms | 📋 | | ⛔ | | 35463673 | The Therapeutic Effect of Coriolus versicolor Fruiting Body on STZ-Induced ICR Diabetic Mice |
Turnip | 📋 | | ⛔ | | 34886781 | Aqueous Extract of Brassica rapa Exerts Antihyperglycemic Activity in Streptozotocin-induced Diabetic Rats |
Vitamin B2 | 📋 | ✍ | ⛔ | | 35680173 | Efficacy and safety of the combined metabolic medication, containing inosine, nicotinamide, riboflavin and succinic acid, for the treatment of diabetic neuropathy: a multicenter randomized, double-blind, placebo-controlled parallel group clinical trial (CYLINDER) |
Vitamin B7 | 📋 | ✍ | ⛔ | | 28335416 | Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin-Potential for Preventing or Slowing the Progression of Diabetic Complications |
Water Chestnut | 📋 | ✍ | ⛔ | | 35208513 | Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet |
Xylitol | 📋 | ✍ | ⛔ | | 35761691 | Whey protein and xylitol complex alleviate type 2 diabetes in C57BL/6 mice by regulating the intestinal microbiota |
Acemannan | 📋 | | | | 37776926 | Acemannan ameliorates STZ-activated diabetes by attenuating high glucose via inhibiting inflammatory cytokines and apoptosis pathway |
Alfalfa | 📋 | | ⛔ | | 38257240 | Evaluating the Antioxidant and Antidiabetic Properties of Medicago sativa and Solidago virgaurea Polyphenolic-Rich Extracts |
Almond Oil | 📋 | | ⛔ | | 31428332 | Co-ingestion of whole almonds and almond oil with carbohydrate suppresses postprandial glycaemia in mice in an insulin-dependent and insulin-independent manner |
Aloesin | 📋 | | | | 26265996 | Aloesin as a Medical Food Ingredient for Systemic Oxidative Stress of Diabetes |
Aloin | 📋 | | | | 33456413 | Barbaloin Treatment Contributes to the Rebalance of Glucose and Lipid Homeostasis of Gestational Diabetes Mellitus Mice |
Alpha GPC | 📋 | ✍ | ⛔ | | 30582404 | Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-Ay mice |
Amino Acids | 📋 | | | | 37755297 | Unlocking the Potential: Amino Acids' Role in Predicting and Exploring Therapeutic Avenues for Type 2 Diabetes Mellitus |
Asparagus | 📋 | | ⛔ | | 35752344 | Furostanol saponins from Asparagus racemosus as potential hypoglycemic agents |
Beta-Alanine | 📋 | ✍ | ⛔ | | 36513312 | Oat β-Glucan Ameliorates Diabetes in High Fat Diet and Streptozotocin-induced Mice by Regulating Metabolites |
Beta-Lapachone | 📋 | | | | 35738116 | β-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function |
Black Tea Polyphenols | 📋 | | | | 29592809 | Exploring the potential of black tea based flavonoids against hyperlipidemia related disorders |
Bladderwrack | 📋 | ✍ | ⛔ | | 37625739 | Fucus vesiculosus polysaccharide alleviates type 2 diabetes in rats via remodeling gut microbiota and regulating glycolipid metabolism-related gene expression |
Boric Acid | 📋 | ✍ | ⛔ | | 37830831 | Success in treating wounds with local boric acid: a case study |
Boron | 📋 | ✍ | ⛔ | | 27908411 | Boron Supplementation Improves Bone Health of Non-Obese Diabetic Mice |
Bread | 📋 | | | | 38528644 | Sourdough bread as nutritional intervention tool for improvement of cognitive dysfunction in diabetic rats |
Camellia | 📋 | | ⛔ | | 38073976 | Neurohistopathological Alterations Induced by Theobroma Cacao and Camellia Sinensis Extracts in Diabetic Male Wistar Rats |
Camphor | 📋 | ✍ | ⛔ | | 33084110 | Modulation of the antioxidant defense system in liver, kidney, and pancreas tissues of alloxan-induced diabetic rats by camphor |
CAPE | 📋 | | | | 15642285 | Effects of Caffeic Acid Phenethyl Ester on Lipid Peroxidation and Antioxidant Enzymes in Diabetic Rat Heart |
Celery | 📋 | | ⛔ | | 34371645 | Evaluation of the Antidiabetic Potential of Extracts of Urtica dioica, Apium graveolens, and Zingiber officinale in Mice, Zebrafish, and Pancreatic β-Cell |
Chebulinic Acid | 📋 | | | | 30189210 | Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation |
Chili Pepper | 📋 | | ⛔ | | 36907948 | Enhanced hypoglycemic bioactivity via RAS/Raf-1/MEK/ERK signaling pathway by combining capsaicin and QUERCETIN from chili peppers |
Chitosan | 📋 | ✍ | ⛔ | | 36547931 | Antidiabetic Properties of Chitosan and Its Derivatives |
Copper | 📋 | ✍ | ⛔ | | 36238639 | The Molecular Mechanisms of Defective Copper Metabolism in Diabetic Cardiomyopathy |
Coriander Essential Oil | 📋 | ✍ | ⛔ | | 35326092 | Coriander Oil Reverses Dexamethasone-Induced Insulin Resistance in Rats |
Cucumber | 📋 | | ⛔ | | 33214339 | Cucumis sativus and Cucurbita maxima extract attenuate diabetes-induced hepatic and pancreatic injury in a rat model |
Cumin | 📋 | | ⛔ | | 35608174 | Phytochemical screening of ethanolic extracts of Cuminum cyminum L. seeds along with the evaluation of antidiabetic properties by molecular docking approach |
D-Limonene | 📋 | ✍ | ⛔ | | 37322623 | L-limonene reduces aortic artery atherosclerosis by inhibiting oxidative stress/inflammatory responses in diabetic rats fed high-fat diet |
D-Ribose | 📋 | ✍ | ⛔ | | 33791005 | D-ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review) |
Delphinidin | 📋 | | | | 30865689 | The natural drug DIAVIT is protective in a type II mouse model of diabetic nephropathy |
Diosmetin | 📋 | | | | 34091150 | Diosmetin ameliorate type 2 diabetic mellitus by up-regulating Corynebacterium glutamicum to regulate IRS/PI3K/AKT-mediated glucose metabolism disorder in KK-Ay mice |
Dragon Fruit | 📋 | | ⛔ | | 28886195 | Effect of dragon fruit on glycemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis |
Eclipta Alba | 📋 | ✍ | | | 38562322 | Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models |
EDTA | 📋 | ✍ | ⛔ | | 21271438 | Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract |
Eleuthero | 📋 | ✍ | ⛔ | | 37467688 | Syringin alleviates hepatic fibrosis by enhancing autophagic flux and attenuating ER stress-TRIB3/SMAD3 in diabetic mice |
Fennel Essential Oil | 📋 | ✍ | ⛔ | | 38139998 | Fennel Essential Oil as a Complementary Therapy in the Management of Diabetes |
Feverfew | 📋 | ✍ | ⛔ | | 24125916 | St. John's Wort Seed and Feverfew Flower Extracts Relieve Painful Diabetic Neuropathy in a Rat Model of Diabetes |
Fish | 📋 | | ⛔ | | 35631289 | Association of Dietary Fish and n-3 Unsaturated Fatty Acid Consumption with Diabetic Nephropathy from a District Hospital in Northern Taiwan |
Ganoderic Acid | 📋 | | | | 27649729 | Comparison of the Chemical Profiles and Antioxidant and Antidiabetic Activities of Extracts from Two Ganoderma Species (Agaricomycetes) |
Garlic Oil | 📋 | | ⛔ | | 33739409 | Ameliorative effects of garlic oil on FNDC5 and irisin sensitivity in liver of streptozotocin-induced diabetic rats |
Ginkgetin | 📋 | | | | 34148304 | Ginkgetin alleviates high glucose-evoked mesangial cell oxidative stress injury, inflammation, and extracellular matrix (ECM) deposition in an AMPK/mTOR-mediated autophagy axis |
Glutathione | 📋 | ✍ | ⛔ | | 38397782 | The Role of Glutathione and Its Precursors in Type 2 Diabetes |
Glycine | 📋 | ✍ | ⛔ | | 35052658 | GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study |
Goat Milk | 📋 | | ⛔ | | 35761566 | Phosphoproteomics reveals that camel and goat milk improve glucose homeostasis in HDF/STZ-induced diabetic rats through activation of hepatic AMPK and GSK3-GYS axis |
Haskap | 📋 | | | | 24521846 | Dietary Anthocyanin-Rich Haskap Phytochemicals Inhibit Postprandial Hyperlipidemia and Hyperglycemia in Rats |
Helichrysum Essential Oil | 📋 | ✍ | ⛔ | | 34451910 | Formulation and Evaluation of Helichrysum italicum Essential Oil-Based Topical Formulations for Wound Healing in Diabetic Rats |
HMB | 📋 | ✍ | ⛔ | | 38004100 | Arginine and Lysine Supplementation Potentiates the Beneficial β-Hydroxy ß-Methyl Butyrate (HMB) Effects on Skeletal Muscle in a Rat Model of Diabetes |
Horsetail Grass | 📋 | ✍ | ⛔ | | 35529823 | Protective effects of Equisetum arvense methanolic extract on testicular tissue disorders in streptozotocin-induced diabetic murine model |
Icaritin | 📋 | | | | 37992492 | The protective effects of icariin against testicular dysfunction in type 1 diabetic mice Via AMPK-mediated Nrf2 activation and NF-κB p65 inhibition |
Indian Mulberry | 📋 | ✍ | ⛔ | | 34693116 | Effects of Root Extract of Morinda officinalis in Mice with High-Fat-Diet/Streptozotocin-Induced Diabetes and C2C12 Myoblast Differentiation |
Jackfruit | 📋 | | ⛔ | | 35335251 | Inhibitory Effect of Polyphenols from the Whole Green Jackfruit Flour against α-Glucosidase, α-Amylase, Aldose Reductase and Glycation at Multiple Stages and Their Interaction: Inhibition Kinetics and Molecular Simulations |
Jasmine | 📋 | | ⛔ | | 35685730 | Integrating In Silico and In Vitro Approaches to Screen the Antidiabetic Properties from Tabernaemontana divaricata (Jasmine) Flowers |
L-Tryptophan | 📋 | ✍ | ⛔ | | 35088560 | Dietary tryptophan and the risk of obesity and type 2 diabetes: Total effect and mediation effect of sleep duration |
Lavender Essential Oil | 📋 | ✍ | ⛔ | | 34217127 | The effects of aromatherapy massage with lavender essential oil on neuropathic pain and quality of life in diabetic patients: A randomized clinical trial |
Lemon Essential Oil | 📋 | ✍ | ⛔ | | 37025967 | Expression of VEGF and CD-31 in traumatic ulcer of diabetic Wistar rats after application of Citrus limon peel essential oil |
Lemon Verbena | 📋 | | ⛔ | | 32520695 | Antihyperglycemic and Antihyperlipidemic Effects of Lippia citriodora in Rats |
Lemongrass | 📋 | ✍ | ⛔ | | 32736056 | Cymbopogon citratus (DC.) Stapf mitigates ER-stress induced by streptozotocin in rats via down-regulation of GRP78 and up-regulation of Nrf2 signaling |
Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 38541661 | Influence of Lemongrass Essential Oil (Cymbopogon flexuosus) Supplementation on Diabetes in Rat Model |
Lentil | 📋 | | ⛔ | | 38337705 | Twelve Weeks of Daily Lentil Consumption Improves Fasting Cholesterol and Postprandial Glucose and Inflammatory Responses-A Randomized Clinical Trial |
Lime | 📋 | | ⛔ | | 32539198 | Citrus Hystrix Leaf Extract Attenuated Diabetic-Cataract in STZ-rats |
Lovage | 📋 | | ⛔ | | 32922483 | Antidiabetic Properties of Hydroalcoholic Leaf and Stem Extract of Levisticum officinale: An implication for α-amylase Inhibitory Activity of Extract Ingredients through Molecular Docking |
Maca Root | 📋 | ✍ | ⛔ | | 36051487 | Extraction, Characterization, and Structure of a Novel Heteropolysaccharide from Lepidium sativum and Its Effects on Wound Healing in Diabetic Rats |
Marjoram | 📋 | | ⛔ | | 35036595 | Optimization of ultrasonic-assisted extraction of polyphenols from the polyherbal formulation of Cinnamomum verum, Origanum majorana, and Origanum vulgare and their anti-diabetic capacity in zebrafish ( Danio rerio) |
Matcha Tea | 📋 | | | | 19735169 | Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats |
Minerals | 📋 | | | | 32585827 | Role of Minerals and Trace Elements in Diabetes and Insulin Resistance |
Mint | 📋 | | ⛔ | | 37496047 | Exploring the antibacterial, antidiabetic, and anticancer potential of Mentha arvensis extract through in-silico and in-vitro analysis |
Mustard | 📋 | | ⛔ | | 37292279 | In vivo antidiabetic effects of phenolic compounds of spinach, mustard, and cabbage leaves in mice |
NAD | 📋 | | | | 36351515 | NAD+ attenuates cardiac injury after myocardial infarction in diabetic mice through regulating alternative splicing of VEGF in macrophages |
Neem Oil | 📋 | ✍ | ⛔ | | 23413284 | The use of an extract of Hypericum perforatum and Azadirachta indica in advanced diabetic foot: an unexpected outcome |
Oak Bark | 📋 | ✍ | ⛔ | | 18836324 | Evaluation of Bensal HP for the treatment of diabetic foot ulcers |
Oak Gall | 📋 | ✍ | ⛔ | | 34382850 | Quercus infectoria gall extract aids wound healing in a streptozocin-induced diabetic mouse model |
Oleic Acid | 📋 | | ⛔ | | 35265127 | Oleic Acid and Succinic Acid Synergistically Mitigate Symptoms of Type 2 Diabetes in Streptozotocin-Induced Diabetic Rats |
Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 33112826 | Association of n-6 PUFAs with the risk of diabetic retinopathy in diabetic patients |
Oolong Tea | 📋 | | ⛔ | | 35321328 | Special Thai Oolong Tea: Chemical Profile and In Vitro Antidiabetic Activities |
Orange Essential Oil | 📋 | ✍ | ⛔ | | 32848717 | Computational and Pharmacological Evaluation of Carveol for Antidiabetic Potential |
Oregano Essential Oil | 📋 | ✍ | ⛔ | | 32806984 | Turmeric/Oregano Formulations for Treatment of Diabetic Ulcer Wounds |
Oyster Mushrooms | 📋 | | ⛔ | | 34798266 | Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity |
Pantethine | 📋 | ✍ | ⛔ | | 2963604 | Lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus |
Parsley | 📋 | | ⛔ | | 27069727 | Hepatoprotective effects of parsley, basil, and chicory aqueous extracts against dexamethasone-induced in experimental rats |
Parthenolide | 📋 | | | | 24125916 | St. John's Wort Seed and Feverfew Flower Extracts Relieve Painful Diabetic Neuropathy in a Rat Model of Diabetes |
Patchouli | 📋 | ✍ | ⛔ | | 37071615 | Preventive Activity of Patchouli Alcohol Against Colorectal Cancer and Diabetes |
PEA | 📋 | ✍ | ⛔ | | 36057884 | A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain |
Pear | 📋 | | ⛔ | | 28186516 | Apple and pear consumption and type 2 diabetes mellitus risk: a meta-analysis of prospective cohort studies |
Pecan | 📋 | | ⛔ | | 36822079 | Pecan-enriched diet improves cholesterol profiles and enhances postprandial microvascular reactivity in older adults |
Pelargonidin | 📋 | | | | 31322351 | Pelargonidin-3- O-glucoside Derived From Wild Raspberry Exerts Antihyperglycemic Effect by Inducing Autophagy and Modulating Gut Microbiota |
Phosphatidylcholine | 📋 | ✍ | ⛔ | | 32198672 | Dietary intake of choline and phosphatidylcholine and risk of type 2 diabetes in men: The Kuopio Ischaemic Heart Disease Risk Factor Study |
Phytoestrogens | 📋 | | ⛔ | | 34051210 | The controversy on the beneficial effect of phytoestrogens in diabetic treatment in postmenopausal women |
Plum | 📋 | | ⛔ | | 33178838 | Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats |
Progesterone | 📋 | ✍ | ⛔ | | 36205489 | Protective assessment of progesterone and its receptor on experimental diabetic neuropathy: Anti-oxidant and anti-inflammatory effects |
Prunella Vulgaris | 📋 | ✍ | ⛔ | | 34692849 | Study on the Mechanism of Prunella Vulgaris L on Diabetes Mellitus Complicated with Hypertension Based on Network Pharmacology and Molecular Docking Analyses |
Quercitrin | 📋 | | | | 21713411 | Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues |
Rapeseed Oil | 📋 | ✍ | | | 36542921 | Inhibitory mechanism of phenolic compounds in rapeseed oil on α-amylase and α-glucosidase: Spectroscopy, molecular docking, and molecular dynamic simulation |
Rose | 📋 | | | | 27642329 | Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats |
Royal Jelly | 📋 | ✍ | ⛔ | | 36056641 | Glucose metabolism enhancement by 10-hydroxy-2-decenoic acid via the PI3K/AKT signaling pathway in high-fat-diet/streptozotocin induced type 2 diabetic mice |
Salt | 📋 | | ⛔ | | 33524391 | Dietary sodium restriction alters muscle lipidomics that relates to insulin resistance in mice |
SAMe | 📋 | ✍ | ⛔ | | 30582404 | Anti-diabetic effect of S-adenosylmethionine and α-glycerophosphocholine in KK-Ay mice |
Sardine | 📋 | | ⛔ | | 33932804 | Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: An interventional, randomized and controlled trial |
Saw Palmetto | 📋 | ✍ | ⛔ | | 32885876 | Diabetic complications and oxidative stress: The role of phenolic-rich extracts of saw palmetto and date palm seeds |
Sesamol | 📋 | | | | 37885753 | Sesamol combats diabetogenic effects of atorvastatin through GLUT-4 expression and improved pancreatic viability |
Shensong Yangxin | 📋 | ✍ | | | 25267579 | Shensong Yangxin Capsule prevents diabetic myocardial fibrosis by inhibiting TGF-β1/Smad signaling |
Spearmint | 📋 | | ⛔ | | 29769013 | Antidiabetic Effect of Spearmint in Streptozotocin-Induced Diabetic Rats |
Sunflower | 📋 | | ⛔ | | 34540481 | Therapeutic Effect of Sunflower Seeds and Flax Seeds on Diabetes |
Tamarind | 📋 | | ⛔ | | 26632284 | Medicinal Plants Traditionally Used for Treatment of Obesity and Diabetes Mellitus - Screening for Pancreatic Lipase and α-Amylase Inhibition |
Tea Polysaccharides | 📋 | | | | 25820466 | Pu-erh tea polysaccharides decrease blood sugar by inhibition of α-glucosidase activity in vitro and in mice |
Theabrownins | 📋 | | | | 35088787 | Theabrownin-targeted regulation of intestinal microorganisms to improve glucose and lipid metabolism in Goto-Kakizaki rats |
Thyme Essential Oil | 📋 | | ⛔ | | 33995021 | Chemical Composition, Antioxidant Potential, and Blood Glucose Lowering Effect of Aqueous Extract and Essential Oil of Thymus Serrulatus Hochst. Ex Benth |
Tongkat Ali | 📋 | ✍ | ⛔ | | 32708678 | The Powdered Root of Eurycoma longifolia Jack Improves Beta-Cell Number and Pancreatic Islet Performance through PDX1 Induction and Shows Antihyperglycemic Activity in db/db Mice |
Watermelon | 📋 | | ⛔ | | 34981526 | Watermelon (Citrullus lanatus) leaf extract attenuates biochemical and histological parameters in high-fat diet/streptozotocin-induced diabetic rats |
Wenxin Keli | 📋 | ✍ | ⛔ | | 32104528 | Wenxin Keli Regulates Mitochondrial Oxidative Stress and Homeostasis and Improves Atrial Remodeling in Diabetic Rats |
White Mushrooms | 📋 | | ⛔ | | 36092487 | The effects of hot air-dried white button mushroom powder on glycemic indices, lipid profile, inflammatory biomarkers and total antioxidant capacity in patients with type-2 diabetes mellitus: A randomized controlled trial |
Yohimbine | 📋 | ✍ | | | 34345380 | Effects of intraperitoneal and intracerebroventricular injection of cinnamaldehyde and yohimbine on blood glucose and serum insulin concentrations in ketamine-xylazine induced acute hyperglycemia |